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Author: Subject: pyridine alternative to 4-dmap
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[*] posted on 8-7-2008 at 22:42
pyridine alternative to 4-dmap


4-dmap is the desirably catalyst for acetylation. However the high cost, low availability, and toxicity, make it undesirable.

Acetic anhydride is a good acetylating reagent itself but it taked days at elevated temperatures for this to acheive desired acetylation. I have also read that pyridines are great catalysts to assist acetylation. I am wondering if regular pyridine can be used in place of 4-dmap (perhaps in excess) to get the same catalyst effect at room temperature, maybe let sit a little longer tho.
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