soma78
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NCS-chlorination
Hello friends,
Nice and thrilled to join you.
I have a question. Is aryl chlorination possible by using NCS?
Are there any literature precedence
Thank You
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Nicodem
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Yes, it is possible to use NCS for the chlorination or aromates.
Yes, there are literature examples.
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jizmaster
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http://www.organic-chemistry.org/chemicals/oxidations/n-chlo...
Looks like it might need a catalyst, other acids might work. Though the substrates in that first example weren't particularly electron rich.
Alternatively N-chlorosaccharin can be used, it should be more reactive than the succinimide and it sounds easy to make:
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S...
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soma78
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Thanks jizmaster for the alternative method.
I will look into literature.
thanks
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