Sciencemadness Discussion Board

Acetylation of sulphate salts

conducter - 8-11-2007 at 02:16

Acetylation with acetic anhydride ive always seen take place on freebase compounds.

And no one has been able to tell me otherwise... but ive got a USP pharmaceuticul grade compound that is usually acetylated as its freebase. However since its in its pure state but has a sulphate attached to it, can that be used directly in an acetylation?

organometallic - 8-11-2007 at 12:51

Why not convert to the freebase form? This is done I believe with ammonia; If i'm wrong please correct me with a minimum of flaming :p
PS, you may have better luck asking at www.wetdreams.ws

conducter - 8-11-2007 at 15:12

well that is certainly possible, i was just wondering if it was possible. It would save alot of hassle because the acetylation requires anhydrous conditions so im trying to avoid using water at all.

Sauron - 8-11-2007 at 17:44

Is this a di-acetylation by any chance?

conducter - 8-11-2007 at 18:02

yes, but not of any illegal compounds.

chemrox - 8-11-2007 at 22:39

a diactylation of a pharmaceutical sulfate that is not an illegal compound? I guess not if you have a prescription. Around here those are three pages. ahem! Also, if you can't liberate a freebase you better stay away from acetylations. The one you're thinking of is notorious for fires and explosions.

anyway, go here: www.wetdreams.ws

[Edited on 8-11-2007 by chemrox]

vulture - 9-11-2007 at 15:25

Unless you name the actual compound, I'm gonna close this for being a drug thread.

conducter - 9-11-2007 at 17:27

acetyl salicylicacid

bio2 - 9-11-2007 at 17:45

lol, since when is aspirin a sulfate salt

conducter - 9-11-2007 at 17:52

haha well i guess its all just hypothetical then...

vulture - 10-11-2007 at 03:57

Haha. Thread closed.

Take your cooking bussiness elsewhere.