Sciencemadness Discussion Board

A-alkoxyexpoxide from aromatic ketones

smartgene1 - 4-5-2018 at 03:39

do any body here know how to make a alpha alkoxy epoxide from aromatic ketones pls help I appreciated

Sigmatropic - 4-5-2018 at 05:50

The naming is ambiguous, please include a drawing or use iupac nomenclature.

The only hit I get is:
https://www.sciencedirect.com/science/article/pii/S004040201...

Now off of the top of my hat I know that epoxide have acidic protons. See for example the discussion section on http://orgsyn.org/demo.aspx?prep=v94p0234.
Maybe one can make alpha alkoxy epoxides by addition to a carbonyl compound?
Quote:

For reviews on lithiated epoxides, see: (a) Satoh, T. Chem. Rev. 1996, 96, 3303-3326.[CrossRef] (b) Doris, E.; Dechoux, L.; Mioskowski, C. Synlett 1998, 337-343.[CrossRef] (c) Hodgson, D. M.; Gras, E. Synthesis 2002, 1625.[CrossRef](d) Hodgson, D. M.; Tomooka, K.; Gras, E. Top. Organomet. Chem. 2003, 5, 217-250.[CrossRef] (e) Hodgson, D. M.; Bray, C. D.; Humphreys, P. G. Synlett 2006, 1-22.[CrossRef] (f) Capriati, V.; Florio, S.; Luisi, R. Chem. Rev. 2008, 108, 1918-1942.[CrossRef]



smartgene1 - 4-5-2018 at 06:39

2-Methoxy-3-phenyloxirane I think I'm missing a methyl group in the name