As already mentioned by me at another topic: http://www.sciencemadness.org/talk/viewthread.php?tid=80658&... , alkyl chlorides can be achieved from any kind of primary, secondary, terciary or
benzylic alcohols, with TCCA and Triphenylphosphine. Archive attached below.
Other way, without the use of nasty and hard to get thionyl chloride or PCl3, PCl5 or POCl3 either, you can get the chloride from alcohol reacting the
late with Cyanuric chloride and DMF in dichloromethane media, as attached below:
both methods will give you high yields, as you can read at the papers.
EDITED:
[Edited on 15-7-2018 by Chemi Pharma] |