morsagh - 26-5-2016 at 11:51
Please guys, can you give me some links for full procedure of alpha-aminoacid synthesis? I can´t find anything about synthesis through
alpha-haloacids.
DJF90 - 26-5-2016 at 13:17
One of the common methods is Strecker synthesis, whereby an aldehyde is treated with an ammonia source and alkali cyanide salt to afford the
alpha-amino nitrile, which is then hydrolised to the alpha-amino acid. The intermediate a-aminonitrile may also useful for further elaboration.
zed - 26-5-2016 at 13:53
http://www.orgsyn.org/demo.aspx?prep=CV1P0298
Two methods are given herein. Seems to me, in most cases, yields are better.....utilizing alpha-BROMO-acids.
Further:
https://books.google.com/books?id=qSnSCgAAQBAJ&pg=PA1041...
[Edited on 26-5-2016 by zed]
[Edited on 26-5-2016 by zed]
Eddygp - 26-5-2016 at 14:45
The Strecker synthesi is the classical approach, but you need a cyanide salt.
morsagh - 27-5-2016 at 09:27
I want some papres where is hell-zelinsky synthesis.