Sciencemadness Discussion Board

andrafinil

CrossxD - 17-5-2016 at 07:53

hallo
I found this https://www.erowid.org/archive/rhodium/chemistry/adrafinil.m... and I like to try it but I dont have any thiourea and diphenyl methane.
Is possible to make thiourea from calcium cyanamide and hydrogen sulphide? And How I can make diphenyl methane? from phenol and toluene?
Thank you so much :DD

careysub - 17-5-2016 at 12:05

You might look at the modafinil synthesis on the same page using benzhydrol (there is also a thread on this particular synthesis on SM).

Modafinil is generally preferable to adrafinil (which is actually a modafinil pro-drug it is metabolized into modafinil to be effective). It is somewhat more potent, takes effect faster, does not require that it be taken in an empty stomach, and had fewer adverse side effects.

Benzhydrol can be prepared from benzophenone, with sodium borohydride or zinc dust as reducing agents.

http://www.chemistry.mcmaster.ca/~chem3d3/old-labmanual/3d3e...

http://www.orgsyn.org/demo.aspx?prep=cv1p0090


Attachment: Example_Expt_Writeup.pdf (176kB)
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Attachment: chem360_lm.pdf (1MB)
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Metacelsus - 17-5-2016 at 17:43

You might be able to extract thiourea from some silver tarnish removers (they contain 5-7% of it; see https://householdproducts.nlm.nih.gov/cgi-bin/household/bran...).

Alternatively, you could buy it on eBay.

[Edited on 5-18-2016 by Metacelsus]

careysub - 17-5-2016 at 18:26

Thiourea can be obtained in the U.S. also from:
Elemental Scientific LLC: $10.99 for 4 oz
Firefox-FX: $13/lb
Amazon.com: $9/3 oz

CuReUS - 18-5-2016 at 04:46

there is another route you could try
1.synthesis of 2-benzhydrylsulfanylacetic acid from benzhydrol and thioglycolic acid
http://pubs.acs.org/doi/abs/10.1021/jm00072a019

2.andrafinil from 2-benzhydrylsulfanyl ethyl acetate
http://www.sciencedirect.com/science/article/pii/S0957416604...

Chemi Pharma - 19-5-2016 at 14:00

CrossxD,

the better route to Modafinil that's used by the pharmaceutical community:

Benzoquinone --> benzhydrol --> condensation with thioglycolic acid in TFA --> oxidation of the sulphur with hydrogen peroxide in H2SO4 --> fischer ethyl esterification of the acid --> ammonolisys of the ethyl ester to afford the amide.

If you want Andrafinil, at the latest step, instead of ammonolisys, react the ester with an alkaline solution of hydroxylamine.

Study very hard the papers i attached below and for sure you'll be able to sinthesize a few grams, like i did at the university lab.


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[Edited on 19-5-2016 by Chemi Pharma]

[Edited on 19-5-2016 by Chemi Pharma]

[Edited on 19-5-2016 by Chemi Pharma]

CrossxD - 22-5-2016 at 01:12

Thank you I will try but can I moke thioglycolic acid from chlor acetec acid and hydrogen sulphide? Or is there better way do it?

CuReUS - 22-5-2016 at 08:31

Quote: Originally posted by CrossxD  
but can I moke thioglycolic acid from chlor acetec acid and hydrogen sulphide? Or is there better way do it?

you could make it by decomposing dithioglycolic acid(now don't ask me how to make that :P)
http://link.springer.com/article/10.1023/A%3A1022276812235
but I suggest you buy it since its extremely cheap and not watched.