Hi anyone have any information on the simple synthesis of phosphoethanolamine, because here in Brazil is much talked about for its anticancer
properties.Praxichys - 17-11-2015 at 11:32
It should be pretty easy to make. It's just the phosphoric acid mono-ester of monoethanolamine.
I'd say reflux monoethanolamine with a large excess of phosphoric acid for a couple hours, basify with sodium carbonate, then see what can be
distilled off under vacuum. Or, extract it with some inorganic solvent.
Not sure though. Sigma calls for -20C as a storage temp. Could be unstable.
[Edited on 17-11-2015 by Praxichys]aga - 17-11-2015 at 12:38
It should be pretty easy to make. It's just the phosphoric acid mono-ester of monoethanolamine.
Amazingly, under the tuition of the B&D Science School, i finally have a clue what all of those words mean.
It's a Revelation !AvBaeyer - 17-11-2015 at 18:08
Boiling with phosphoric acid will not give any product. You need a specialized phosphorylating agent such as, for example, dibenzyphopshoryl chloride.
There is a huge literature on this subject (phosphorylation reactions and reagents) and it is relatively easy to find and learn from.
AvBItaBier - 18-11-2015 at 00:57
Hi, i find the simple way, i see various syntheses with complex molecules, gold chloride, barium, etc. Already the largest university researchers have
invented a process by the reaction of the two compounds(mea and phosphoric acid) in an alcoholic medium, washinhg with ethanol and heating at 190
degrees to transform phosphate in phospho and neutralization with calcium and magnesium carbonates with yeld of 90%. the problem is the details, here
patents has no free access.Praxichys - 18-11-2015 at 05:28
Well, phooey. For some reason I assumed phosphates were like borates. It does seem pretty straightforward with the right reagents though. All the
preps in Brauer use POCl3 so they're kind of prohibitive for amateur use.
The only difficult thing to get here is the pyridine.ItaBier - 18-11-2015 at 09:30
Does there exist error in the following way: 1 mol ethanolamine + 1.1 mol of phosphoric acid + 1 mol of absolute ethanol at room temperature. wash the
precipitate with absolute ethanol. Heat the precipitate by 190 C for one hour. neutralizing with calcium carbonate and dissolve in hot distilled
water. wait for the crystallization and drying the precipitate (melting 240 C)DraconicAcid - 18-11-2015 at 12:05
I don't know about the difficulty in forming phosphate esters, but it's going to be a lot tougher to make an ester from ethanolamine than from
ethanol. The amine group is basic, and a better nucleophile than the hydroxyl group of the alcohol.Marvin - 18-11-2015 at 13:10
It's not impossible that method works, but you can't check it with taught chemistry. The first step would produce a salt which might dehydrate to
produce the target on heating. The best way to check would be to look it up in proper literature.
There are a lot of desperate people wanting to believe in cures, something that can be cooked up from industrial chemicals sounds very risky to me.Aqua_Fortis_100% - 1-1-2016 at 20:58
Hi anyone have any information on the simple synthesis of phosphoethanolamine, because here in Brazil is much talked about for its anticancer
properties.
Actually, here the phophoethanolamine made by Prof. Dr. Gilberto Orivaldo Chierice and his team was in the form of the mixed salts of Zn, Ca and Mg
using a modified synthesis (Ca-EAP, Mg-EAP, sold OTC in USA and Europe as supplements).
It should be pretty easy to make. It's just the phosphoric acid mono-ester of monoethanolamine.
I'd say reflux monoethanolamine with a large excess of phosphoric acid for a couple hours, basify with sodium carbonate, then see what can be
distilled off under vacuum. Or, extract it with some inorganic solvent.
Not sure though. Sigma calls for -20C as a storage temp. Could be unstable.
[Edited on 17-11-2015 by Praxichys]
The attached patent say that equimolar amounts could be used with good yields.
MDMa is supposed to be anticancer drug. Go make some MDMA then.
No thanks.
Actually phosphorylethanolamine is an important endogenous substance used to form cell membranes and also as a signaling agent in the body. ItaBier - 3-1-2016 at 10:08
The problem is how to cristalize a viscous liquid like honey.
Brazilian patent:
Attachment: PI0800460.pdf (497kB) This file has been downloaded 908 times
NexusDNA - 4-1-2016 at 07:55
I think it should be pretty straightfoward, just add ethanol and cool it down. You could omit the inert atmosphere too, just bubble some air in to
drive water out.
90% is just too good to believe though...Aqua_Fortis_100% - 4-1-2016 at 08:34
The problem is how to cristalize a viscous liquid like honey.
Brazilian patent:
Like the NexusDNA said, the real problem is not this, cause this liquid is just molten and crude phosphorylethanolamine. I would simply put the molten
thing in a big glass plate to cool down and then break it finely to dissolve it and recrystallise.
Note that phosphorylethanolamine is just the precursor to make the mixed salts that are composed the USP pills -> "1 mol phosphoethanolamine
neutralized by 0,42 mol CaCO3 + 0,11 mol MgCO3 + 0,06 mol ZnCO3" referenced in the USP team patent.
The method they use to neutralize the phosphoethanolamine (mixing the carbonates and the phosphoethanolamine moisting it with water and letting it
react for 5 days at 70°C) maybe can alter the crystal structure of final product and explain the higher biodisponibility of phosphoethanolamine
salts.
Amos - 4-1-2016 at 08:52
I haven't had time to try it myself, but wikipedia states that a high temperature reaction between phosphorus pentoxide and sodium chloride produces
phosphoryl chloride vapor, which could be collected and used to produce the phosphate ester.Aqua_Fortis_100% - 4-1-2016 at 14:06
I haven't had time to try it myself, but wikipedia states that a high temperature reaction between phosphorus pentoxide and sodium chloride produces
phosphoryl chloride vapor, which could be collected and used to produce the phosphate ester.
I wouldnt waste precious P2O5 neither phosphoryl chloride in the synthesis of phosphorylethanolamine since it can be made from
phosphoric acid, maybe you can use for another phosphoric esther that would be hard to make from plain phosphoric acid.
Aqua_Fortis_100% - 6-1-2016 at 10:14
The attached doc GB1092185 is the Hans Nieper / Franz Kohler patent regarding Ca-EAP and a mix of K and Mg aspartates. It is stated that treating with
Ca-EAP alone can develop Mg and K deficiency, so the aspartates of this salts are administred along with Ca-EAP. In the end of the patent in procedure
I and II they say the simplest way how to get Ca-EAP from phosphoethanolamine.
Another attached patent US5068228 is a much more general and interesting document, as it focuses on alkylamino esters of phosphoric acid not just
phosphoethanolamine but its salts and related substances and some possible pharmaceutical uses. They make EAP salts somewhat different, as they
dissolve phosphorylethanolamine in alkaline media, add calcium hydroxide and bubble CO2 and filter calcium phosphate and carbonate. They
state a high yield (88%) although I think this way seems to hydrolise the phosphoric ester to some extent.
Attachment: fosfo-GB1092185A.pdf (241kB) This file has been downloaded 852 times