Sciencemadness Discussion Board

Denatonium Benzoate synthesis

kazaa81 - 18-6-2006 at 07:15

denatonium benzoate, this strange chemical...however, you know it very well! it is added in about every poison chemical substance to prevent ingestion, because of it's extemely bitter taste.

from wikipedia:
[...] Dilutions of as little as 10 ppm are unbearably bitter to most humans [...]

This is surely the compound we would like to synthetize.

Denatonium on wikipedia
http://en.wikipedia.org/wiki/Denatonium

However, the problem is that it is a fairly complicated compound, and even OrgSyn does seem to not have a synthesis for it.

The_Davster - 18-6-2006 at 10:28

Here is a scheme, although it starts from lidocaine, so you may want to start off with a synthesis of lidocaine.

Attachment: denatonium benzoate.pdf (77kB)
This file has been downloaded 2160 times


Misanthropy - 30-8-2006 at 14:49

The reverse to this would be more interesting...

Bitter

MadHatter - 30-8-2006 at 21:29

That was probably the shit my mother put on my fingernails as a child to deter me from
biting them. Didn't work. I bit them anyway.

Swany - 31-8-2006 at 05:33

I found about 100 1.8ml carpules of 2% lidocaine, and will probably be attempting the synthesis soonish.