shrent - 13-4-2006 at 06:23
Hello !
I'm trying one Michael addition reaction between an acrylate based ester with l-alanine as under.
Ph-CO-CH=CH-COOC2H5 + H2N-CH(CH3)-COOH makes : Ph-CO-CH2-CH(COOC2H5)-NH-CH(CH3)-COOH.
But here, the solubility of l-alanine inhibits taking reaction in any solvent like Methanol/ethanol, etc.
Can you suggest something to perform this reaction like, solvent media, making soluble the l-alanine in any solvent & other reaction conditions ?
Regards,
shrent
chochu3 - 10-5-2006 at 03:43
These type of reactions usally need to take out water by azetropic distillation for the reaction can shift forward. Have you tried using a longer
chained alcohol (more carbons).