dhydr8dH2O - 27-7-2005 at 23:22
It is shown that terminal acetylenes can be aminated through simple hydrolisis. But how? By placing the desired acetylenes in DH20 and microwaving.
Ahhh, simply beautiful....but enough admiration, what is desired is the creation of a certain beta amine or even its methylated cousin. Could someone
enlighten another as to what would be the most effective starting materials, with all the numerous possibilities for correct combinations and not
knowing every molecule that exists (at least not the names - all those ethyl-butyl-methyl-propanone-phenyl-etc-etc). Could a wiser one out there help
guide the way to possible combinations?
bio2 - 28-7-2005 at 22:21
.....It is shown that terminal acetylenes can be aminated through simple hydrolisis. .........
Do you have any references to post on this?
Hydrolysis isn't going to put in a nitrogen that doesn't already exist . Terminal meaning the "end" of the molecule has the triple
bond so it seems the amine already has to be on the beta carbon.
More info is needed.
dhydr8dH2O - 4-8-2005 at 03:28
unfortunately no resources than organicscience web page. The only useful journal that could be located seemed to be on a spanish speaking web page,
and links to journals and other resources wither could not be found or cost money. Being poor this is not preferred. 