The biggest problem I've had with 1,4-dioxane is drying it. Holy crap. Fractionating the azeotrope out is impossible given the 12C temp difference.
Melting sodium metal in it for hours until fizzing appeared to stop still yielded azeotrope on distillation. It also cannot be used for grignards as
far as I know, as the molecule chelates magnesium halides and precipitates them forming diorganomagnesium species in solution. |