Sciencemadness Discussion Board

Sulfosalicylic acid

Waffles SS - 9-5-2012 at 20:42

Quote:



Sulfosalicylic acid is used in urine tests to determine urine protein content. The chemical causes the precipitation of dissolved proteins, which is measured from the degree of turbidity.[1]
It is also used for integral colour anodizing.
With water it is used as a shuttle solution for the CAS assay to test for siderophore

Sure sulfonation of salicylic acid by Sulfur Trioxide make Sulfosalicylic acid but it is difficult to make and handle Sulfur Trioxide.

I didnt find any procedure for making SSA just Merck index14 mentioned below reference
Quote:

Literature references: Prepn: Pusca et al., Rev. Chim. (Bucha rest) 13, no. 1, 49-50 (1962), C.A. 57, 14994b (1962).


I am looking for Simple procedure.

I think we can use Sulfuric acid instead of SO3 but reaction happen slowly.and this is so difficult to get rid of sulfuric acid when reaction finished



[Edited on 10-5-2012 by Waffles SS]