Sciencemadness Discussion Board

huang minlon reduction

jcm4679 - 9-1-2012 at 17:16

hey. can anyone help me out with something? after preforming a huang-minlon modification of the wolff-kishner reduction how do you go about separating the hydrazine hydrate, potassium hydroxide, and diethylene glycol from your product after the reaction takes place?? any help at all would really be appreciated.

ScienceSquirrel - 9-1-2012 at 17:23

Dump the lot in ice water, extract with solvent.
Concentrate and distil or crystallise as appropriate.

hankxmen - 26-2-2013 at 19:34

Quote: Originally posted by ScienceSquirrel  
Dump the lot in ice water, extract with solvent.
Concentrate and distil or crystallise as appropriate.

would you be able to expand on other procedures/seperations on this reduction?

arsphenamine - 26-2-2013 at 22:14

The Huang-Minlon modification is covered in Wikipedia and mentions a refereed procedure in Organic Syntheses, Coll. Vol. 4, p.510 (1963).

A search on the latter should give you the information you need.

hankxmen - 26-2-2013 at 23:11

thanks!!! got it to work so helpful

[Edited on 27-2-2013 by hankxmen]