Sciencemadness Discussion Board

chloramphenicol hemi succinate synthesis

ptlmayank - 14-11-2011 at 02:35

i had synthesised chloramphenicol hemi succinate from chormaphenicol but getting poor yield and product was contaminated with raw material as well as 2 other impurity.

kindly suggest me the most possibility of impurity and which probably parameter affect the reaction.




[Edited on 17-11-2010 by ptlmayank]



[Edited on 17-11-2010 by ptlmayank]

untitled.bmp - 203kB

Nicodem - 14-11-2011 at 13:28

Quote: Originally posted by ptlmayank  
kindly suggest me the most possibility of impurity and which probably parameter affect the reaction.

Provide the references and/or the experimental, else there is no point in making guesses or giving obsolete suggestions.
The only suggestion for side products I can give without any of the required information is the obvious regioisomeric ester and the double succinate ester.

PS: Please open referenceless threads only in the Beginnings section where I'm moving this.