Has any hobbyists ordered chemicals from Sigma-Aldrich?

Quote: Originally posted by SuperOxide

From what I gather, it's nearly impossible to buy chemicals from Sigma unless you're a college, institution, or a company. But it looks like NileRed is able to order from them? As well as some other youtubers (eg: Ben from Applied Science). [Edited on 8-8-2021 by SuperOxide]

Quote: Originally posted by Syn the Sizer

One though is the 4-HO-benzaldehyde is hard to find, there is a bit of an idea for a route to it. You could nitrate toluene, isolate the para isomer. Reduce to the amine, react with NaNO2 and HCl to for the azo compound. React with NaOH for 4-HO-toluene, than Etard reaction to the aldehyde. But that is a bit of a process. There are other routes which may also be more desirable just to not have to deal with chromyl chloride.

Quote: Originally posted by teodor

I will just repeat what I said before. I think buying from companies who don't want to sell chemicals for individuals works against amateur chemistry. And making video dedicated for individuals/amateurs which contains demonstration of those companies products is just silly. Your subscribers will not be able to buy it. You don't support amateur chemistry this way. Let's support companies who DO SELL. They always have ability to advertise their products here by the way. Or through youtube videos, contacting people who make the videos. Of course Sigma produce a big number of different compounds of first class quality. But I believe any person (for example somebody who is making video) can just do rebranding. But they do exactly opposite things. They show to everybody that they CAN buy from Sigma. But this create a false reality. Those people who show on their video bottles with Sigma label are not from amateurs camp. Period.

What's ligma?

Thanks for that, I will start referencing to sigma now by this name as well, that's really great

Quote: Originally posted by CouchHatter

I bought a 1L sep funnel from sigma in 2018 as an individual. Maybe things change, or they treat glassware differently. I just wrote them an email detailing my home lab setup, chemical storage solutions, and why I wanted the funnel.

Quote: Originally posted by Fyndium

I bought my equipment very originally from German supplier called Carl-Roth back in 2007. Their equipment was expensive, 500mL drop funnel with compensator was 100€. Later I purchased an used Schott 2L sep from eBay for 80€. This has been my workhorse for a decade now. Chemland sells 5L sep funnel for 100€ and 10L for 200€.

The chemical supply place down town from me has a nice big 4L sep funnel.
I went there when I was just getting into chemistry, so seeing a 4L sep funnel was pretty awesome to me:

I don't remember the price, but I remember it was pretty good. I have a feeling he had been holding onto it for some time and was trying to get rid of it. I was like "whoa... that sep funnel is huge..." "Yeah. Would you like to buy it???" "Nah" "Oh.... ok... ::sadface::" lol.

Quote: Originally posted by karlos³

Yeah, via resellers, but here in europe. How is that american well known reseller called, they usually do that even in small amounts? You should write those guys and get a quote for the prices for your respective compounds in the respective quantities(also get quotes from TCI, fisher and ABCR, those are often cheaper!), tell them the CAS and where you want it from preferably. Thats how it usual goes.

No, as its not of use for you since you're in the states, they don't ship outside of the EU.

But I remembered the american resellers name!
I meant the one called chemsavers, contact them per mail and tell them what(with CAS), the supplier you want it from and the amount, and they'll give you a price quotation then.
Also, don't waste time explaining what you want it for if they aren't asking.

People from here, like na-cyanide, mario840, and some others, could get it for you too from sigma.
But you're better off if you first compare prices, as ligma(hehe ) is not known for its low prices.
TCI is almost always less costly, and also often has stuff in even smaller packaging sizes(but of course, much more costly... ).

Quote: Originally posted by karlos³

But I remembered the American resellers name! I meant the one called chemsavers, contact them per mail and tell them what(with CAS), the supplier you want it from and the amount, and they'll give you a price quotation then. Also, don't waste time explaining what you want it for if they aren't asking.

Quote: Originally posted by karlos³

People from here, like na-cyanide, mario840, and some others, could get it for you too from sigma. But you're better off if you first compare prices, as ligma(hehe ) is not known for its low prices. TCI is almost always less costly, and also often has stuff in even smaller packaging sizes(but of course, much more costly... ).

Quote: Originally posted by karlos³

But I remembered the american resellers name! I meant the one called chemsavers, contact them per mail and tell them what(with CAS), the supplier you want it from and the amount, and they'll give you a price quotation then. Also, don't waste time explaining what you want it for if they aren't asking.

Got the shipment in from Chemsavers :-)



- 100g of 4-hydroxybenzaldehyde ($49.00)
- 100mL of Pyrrolidine ($36)
- 500mL of 4-Methylpyridine ($63 - which btw is way wayyyyy more than I will probably ever use, but when it's 25mL for $30 or 500mL for $63... May as well pay 2x and get 20x as much)

Pretty much all of the above is way more than I need it for since I only plan on doing a few runs of this synth, but I hate buying such small amounts of a chemical, especially when you get much better deals on just moderate amounts, and the shipping is usually the same.

I haven't used them yet, Mikhail (ChemSavers president) was very reasonable and easy to deal with. And these prices are actually pretty decent as well.

Quote: Originally posted by macckone

The 'know your customer' regulations basically force chemical suppliers to actually ID their customers. Not sure what would trigger that on this order, possibly the 4-hydroxybenzaldehyde. That is used in drug synthesis but it is also used to make vanillin, so it isn't a listed chemical but could be on a watch list of some kind.

Quote: Originally posted by S.C. Wack

To evade certain laws, pyrrolidine versions of drugs have been sold on the street (PCP being first is at the top of the list and this drug was banned years ago), making it a listed precursor chemical in some jurisdictions.

Interesting. I got the impression that the 4-hydroxybenzaldehyde was what required the IUF (intended use form) and ID. But I suppose I could be wrong.

Also, the pyrrolidine smells pretty bad, but nothing near as bad as the 4-methylpyridine, lol. I literally gagged when I was pouring some into the graduation cylinder. That's a first.

I finally got around to making the 1,4-dimethylpyridinium iodide:


I thought it failed at first because of how dark it got (I was expecting it to stay yellow or slightly orange, not dark red), and nothing precipitated out after everything was mixed or during the reflux. But after the reflux and I let it cool, I could see some Schlieren patterns in the mix, so I stuck it in the freezer, and got a hell of a lot of product. I still need to do the workup/recryst before moving onto the actual MOED.

In regards to the 4-hydroxybenzaldehyde, it looks like I can find some other uses for that. The raspberry ketone synth uses it, and it requires some hydrogenation as well which is something I've been wanting to try.

Quote: Originally posted by S.C. Wack

The methylated cpd. has some obvious uses but is not a listed precursor even so. Pyrrolidine on the other hand is used directly as is...karlos decided to bring up exhibit B, where of course the title cpd. can be many other things, substituted in the ring or side chain length, for cathinones which can be and are also amine-substituted...it is said that "LSP" is active at 2-3 mg...and it has been used in the tryptamine area as well, and no doubt elsewhere.