Sciencemadness Discussion Board

Recommendations for synthesis of medicines and other medical organic molecules.

fdnjj6 - 29-7-2020 at 02:31

I am looking into putting my skills as a chemist to the test by making a small array of *US legal* chemicals. I always liked making chemicals that could have some sort of effect on the human body besides harm. Extremely easy chemical synthesis like nitrous oxide or chloroform are out of the picture as any monkey can make these with absolute ease.

Through digging on Wikipedia and other sites, I have found three chemicals I think are fairly possible for an amateur to make:


Chlorobutanol- Fairly easy to make and the only issue is usually recrystallization. It tends to form an oil instead of a crystal strucuture. I would make chloral hydrate but it's regulated and deals with elemental chlorine.


Isopropyl nitrite- Not really a medical chemical, but does have an effect as a potent vasolidator and possible mild euphoria. Fairly easy synthesis via sodium nitrite, isopropyl alcohol, and HCl and the reaction is very controllable if done properly. Big fire hazard as it is very volatile and flammable, but with proper safety equipment and keeping everything cold, this shouldn't be an issue.


Propofol- This would be a very difficult reaction for me. From what I have been able to scrap together, phenol is first sulfonated in hot concentrated sulfuric acid. This serves to add protecting groups. Isopropylation follows which is supposed to be an addition of isopropyl alcohol in HCl. Then the sulfonated product is desulfonated via hot dilute sulfuric acid. I wasn't able to find much on the synthesis that uses obtainable chemicals like phenol, H2SO4, HCl, and isopropyl alcohol and I think this is a synthesis I wouldn't be able to pull off.


Does anyone have some non illegal "drugs" that are feasibly synthesized in an amateur lab? I would need something that isn't piss easy to make like chloroform, but also something that isn't too hard. Multiple steps are okay. Nothing more toxic than 100mg/kg, no halides except for iodine, and preferably something that can be synthesized fairly safely.

Any chemical suggestions or tips to the right direction would be really helpful.

B(a)P - 29-7-2020 at 03:56

Nitroglycerin seems to fit your criteria - not sure about US legality though, also your 'fairly safely' criteria is a bit subjective.
Also these guys have some interesting ideas.
https://fourthievesvinegar.org/

[Edited on 29-7-2020 by B(a)P]

Fery - 29-7-2020 at 04:27

Advanced Practical Medicinal Chemistry
https://www.pdfdrive.com/advanced-practical-medicinal-chemis...

propofol synthesis (from phenol)
http://www.umich.edu/~chemh215/CHEM216/HonorsCup/HC%20250-IV...
you'll be able to do it, do not underestimate yourself

propofol synthesis (from 4-hydroxybenzoic acid - no need to sulfonate, there is COOH instead of SO3H), you can obtain the acid by hydrolysis of parabenes
Attachment: pramanik2014.pdf (412kB)
This file has been downloaded 478 times

Metacelsus - 29-7-2020 at 05:12

Benzocaine is also a good target. You can do toluene -> p-nitrotoluene -> p-nitrobenzoic acid -> p-aminobenzoic acid -> benzocaine

Dr.Bob - 29-7-2020 at 06:54

I second benzocaine or lidocaine, it is a great experiment, and easy to tell if it worked. I taught this in a sophomore chem. course to 20 people a few decades ago, and most got it, but not all, so not a slam dunk. And the yield varied wildly, so a great test of your skills. Luminol is not a drug, but a great target and fun to show kids. Sulfa drugs are also doable targets, depending on what you have available.

For the really ambitious, Viagra and Cialis are possible to make, but not easy at all, but there are several improved newer routes, some using microwave for ceratin steps, some continuous flow steps, and some solid phase catalyts also. I think Stephen Ley published one of them. They are also easy to tell if they worked...



fdnjj6 - 29-7-2020 at 11:02

As far as the recommendation of nitroglycerine goes, I have made vasolidator nitrate esters before. I made erythritol tetranitrate and worked on the synthesis for a couple of months to attempt maximum yields using various nitrate salts. Trinitrophenol was a burn medication for a while and I have made some before as well but it was for energetic testing. The problem is that those were my past days of energetic synthesis and I have been using other organic synthesis to get away from energetic chemistry. Don't get me wrong it was super fun :P and I had actually managed to discover a synthesis of silver acetylide double salt synthesis to get high purity product with ease which many struggle with. Making high explosives in my state is legal but the problem is the unwanted attention you can get from it. The fact that I often have to go through an area that sometimes pulls you aside randomly for bomb sniffing dog checks also puts me at edge. I'd rather not have to explain myself to authorities. So while I am definitely experienced enough to make nitroglycerine and have all of the reagents on hand, I'd rather perform some other chemistry. Thank you for the recommendation and link to the site though!

I will definitely add benzocaine and lidocaine to my list of "drugs" I'll attempt to synthesize. I had looked at a synthesis of benzocaine before but for some reason didn't like something about it. I'll revisit the synthesis and I'll see if it is something I'll attempt. By the sounds of it, it is very doable, so thank you for those recommendations!

I have thought about luminol synthesis and since I will be ordering potassium hydrogen phthalate to make phthalic acid and phthalic anhydride for some pH indicator synthesis (thymolphthalein and the famous phenolphthalein), I may very well try it. I haven't put much effort into looking deeper into the synthesis but from one quick overview of a synthesis route I saw that you need hydrazine. Making hydrazine sulfate to make hydrazine in situ isn't really something I'd want to do. I was watching a video on hydrazine sulfate's synthesis and some pure hydrazine had crystallized out onto the cold beaker during the process. Pure hydrazine is a no go for me due to the whole potent neurotoxin and strong carcinoge thing. I'll look into alternative synthesis and it will be a potential addition to my list of organic molecules to synthesize. Thank you.

[Edited on 29-7-2020 by fdnjj6]

Cou - 29-7-2020 at 11:38

Nitrous oxide and 2-methylbutan-2-ol are legal recreational drugs. Though you need bromoethane for the grignard reaction.

[Edited on 7-29-2020 by Cou]

fdnjj6 - 29-7-2020 at 11:56

Thank you for the reply!

Nitrous oxide is too easy to make. Just heat pure recrystallized ammonium nitrate and dry the gas that is evolved.

While looking through wikipedia I did find 2-methylbutan-2-ol an interesting candidate. I have the glassware needed for a grignard reaction but I'd have to make the bromoethane and dry diethyl ether first. Since grignards are also so unreliable, I don't know how well I could pull off the reaction.

Also a question that popped up is at what point, and how, would you separate the isomers for making benzocaine? So far, the separation of the isomers seems far from trivial. Benzocaine requires the para nitrated product. Meta is formed at a low amount, so ortho would be the main impurity. Someone had mentioned steam distillation to seperate o-nitrotoluene. If I pulled off a steam distillation, the para product should be left behind and could be recrystallized for higher purity. Is this feasible? The boiling points of the isomers are pretty close together so I question how well of a separation I would actually get.

I have a pretty good synthesis of benzoic acid that I would love to try and I could nitrate the benzoic acid. I don't have strong nitric acid though. I need to titrate the dilute nitric acid I have and see how strong it actually is. When I used to perform energetic nitrations I would opt for the nitrate salt method. Is it possible to use an excess of 93% sulfuric acid to pull away enough water to successfully perform the mono nitration? Better yet, does anyone know if a nitration bath prepared using a nitrate salt is viable for the mono nitration of either toluene or benzoic acid? Everything tells me it definitely would work just fine and some water could be included to make sure the acids aren't so concentrated that they begin to favor dinitrated products.

[Edited on 29-7-2020 by fdnjj6]

fdnjj6 - 29-7-2020 at 12:28

Could you separate the two isomers by adding it to chloroform? I don't know how soluble both would be in the chloroform but since the density of chloroform is 1.49 g/cm³ and the density of o-nitrotoluene is 1.1611g/cm^3. Theoretically, would you be able to add the two isomers to chloroform and agitate the isomers to have o-nitrotoluene rise to the top of the chloroform and skim it off? Then purify the p-nitrotoluene via recyrstallization.

karlos³ - 29-7-2020 at 12:47

They usually separate that for methaqualone synthesis by separation because one is a solid and the other is a liquid.

fdnjj6 - 29-7-2020 at 12:53

Yea I saw that one is liquid and the other isn't but how would you separate them? I imagine that p-nitrotoluene is soluble in the ortho product. Threads that discussed the separation said it was difficult.

Syn the Sizer - 29-7-2020 at 15:16

Quote: Originally posted by Cou  
Nitrous oxide and 2-methylbutan-2-ol are legal recreational drugs. Though you need bromoethane for the grignard reaction.

[Edited on 7-29-2020 by Cou]


I had no idea tert-amyl alcohol was a recreational product. I had always though the only alcohol we could consume without hurting ourselves severely was ethanol.

fdnjj6 - 29-7-2020 at 17:37

I believe it even has very similar effects as ethanol.

Cou - 29-7-2020 at 18:29

It's even healthier than ethanol because it doesn't get oxidized to toxic aldehydes or ketones.

karlos³ - 29-7-2020 at 19:19

Thalidomide was pretty easy to make too, by the way.

fdnjj6 - 29-7-2020 at 20:12

Okay so I have the synthesis from toluene to benzocaine figured out. However, it'd be great if someone has some actual lab notes and preparation of this method so I can cross reference the steps and make sure everything will go smoothly.

I'll start by nitrating toluene to mononitrotoluene. I wanted to use benzoic acid at first but the nitro groups don't end up in the position I need them to be at. The isomers will be separated via chilling the crude product. Then the product is recrystallized.

The p-nitrotoluene is then oxidized to p-nitrobenzoic acid using sulfuric acid and KCr2O7. I have found a video that also shows this reaction and they seemingly had success, however, a different preparation I found heated the nitrotoluene with glacial acetic acid before the KCr2O7 step so I am slightly confused. The acetic acid seemed to be a major part of the synthesis yet the video says otherwise. Assuming the video was right, I move on to the next step.

The p-nitrobenoic acid has its nitro group reduced to an amine group via tin/HCl method. I found a preparation of this step online so hopefully it will work.

The final reaction uses the p-aminobenzoic acid and I carry out a Fischer esterification using ethanol and sulfuric acid.

Assuming all of these steps go right, I should get my product. Does this all seem right? I had huge trouble finding preparations documented anywhere for most of these steps so the total synthesis is basically a Frankenstein of other site's methods.

stephill92 - 29-7-2020 at 20:31

Chemplayer has a series on making benzocaine on bitchute, however he did a fischer esterification first and then reduced the nitro group using sodium dithionite solution. Here's the video: https://www.bitchute.com/video/ZWJZPemwJdm5/

fdnjj6 - 29-7-2020 at 21:00

Awesome! I used some of his videos for reference but thought he gave up and failed since I couldn't find a video on p-aminobenzoic acid.

So seeing how he was actually successful in the p-aminobenzoic acid synthesis, it looks like I can use that video for help.

The only thing is that I do want to try the reduction of the nitro group into an amine using the traditional methods of HCl and a metal. I have only found one procedure that uses tin as the metal.

The part that is a little foggy is when they add ammonia to it. It makes sense since it gets rid of the tin ions but what follows is just written weirdly. It says:
"Add concentrated ammonia solution until the solution is just alkaline to litmus and digest the suspension of precipitated hydrated tin oxide on a steam bath for 20 min. Add 10g of filter aid... (they basically vacuum filter and wash the remaining product out of the beaker using hot water)... Concentrate the combined filtrate and washings until the volume has reduced to 157-200 ml:filter off any solid which separates.

Acidify the liquid to litmus (what is that supposed to mean? I'm pretty sure they just want the solution to be mildly acidic) with glacial acetic acid (can other acids be used too? Although I think HCl is strong enough to form salts with the benzocaine, not sure about this step) and evaporate on a water bath until crystals commence to separate; cool in ice; filter the crystals and dry in the steam oven."

The yield is 77%. It just sounds a bit off, I've been researching this all day already and my head hurts, but if I'm undersanding it right, you basically reflux the p-nitrobenzoic acid with HCl and powdered tin, then to precipitate the tin ions you add ammonia, the p-aminobenzoiv acid is deprotonated by the ammonia and forms a salt or complex that is destroyed after acidifying the solution with acetic acid. Then boiling or evaporating the water will leave me with my product which I can perform a fischer esterification on to finally get benzocaine.

fdnjj6 - 29-7-2020 at 21:18

Woah I was watching chemplayer's reduction experiment and he said that they had tried the tin and HCl method on nitrotoluene in a separate video. Anyone have a link? I can't find it.

RogueRose - 29-7-2020 at 22:28

This thread is pretty close to drug production isn't it (against forum rules)? I find it suspicious the 3 things picked are extremely strong sedatives with high potentials for abuse and misuse.

fdnjj6 - 29-7-2020 at 23:15

I didn't mean for it to be. Propofol would require some form of pain reducing agent I believe and it's rather hard to actually use. I am honestly just looking for organic synthesis with purpose. I have been planning phentolphthalein and thymolphthalein synthesis and the reason I don't mention it here is because the synthesis is well documented and easy to reproduce for me. Multi step organic synthesis of benzocaine aren't. Ispopropyl nitrite isn't a good "popper" and that's why it's legal and the butyl version is illegal (I believe). Chlorobutanol is also mainly a hypnotic sedative and isn't good for producing a euphoric effect which is probably why it hasn't been banned yet. It's also highly toxic to the liver. I honestly just want to get away from the energetic chemistry past I have and move on to more applicable and safer synthesis.

It's been a dream of mine to successfully pull off a multistep organic synthesis that ends with a product that is commonly used and has a larger structure than just some simple alkene. I was going to prepare acetaminophen but guess who doesn't have the balls to make acetic anhydride? This guy. Ketene is too much for me as I am still a flowering chemist. I'll never make ketene in fact. It's too much. I love the synthesis of sodium azide and it would use all of the new advanced glassware I have coming in but it is faaaaarrrr too toxic. I have a lot of experience in safety practices and have taught myself a lot of theory, however, there is a lot I still don't know. Explosives gave me a good direction as most were fairly easy to make and the results was always fun. Like I said I want to get away from this type of chemistry. It's not illegal where I live, it's just lots of potential trouble and dangerous.

Just researching the whole synthesis for benzocaine from toluene I have learned so much. I learned various methods to reduce nitro groups to amine groups (I only knew Pd/C method so far), oxidizing the methyl group of toluene to a carboxylic acid, etc. Just loads I've learned. Now, theoretical does me nothing unless I can actually do it practically. Everyone who reads one article on clandestine manufacture and knows the reactions needed and chemicals needed can say they can make it, but in reality it's not that easy.

I am also just seriously trying to test my chemistry skills. I have performed mainly simple reactions but I have an upgrade in glassware coming and lots of time due to the virus so I thought now is the best time to give it a shot.

I assume that the three things I picked were because they were easily made and since they do have potential for some abuse they are more popular. I found out about chlorobutanol through some friends who watch NileRed and found it awesome. Isopropyl due to sodium azide. Propofol by looking at potential chemicals on Wikipedia. I liked the fact that chemicals can have a biological effect too. Just fascinating to me.

If I wanted to make meth or some legal drugs, I wouldn't result to this site. There are plenty of other sites and a lot of sites literally have synthesis for various amphetamines, GHB, LSD, ketamine, MDMA, etc. Many also have drugs that are legal and easy to make but I don't care for the euphoric effects of whippits and stuff like that. I want the chemistry.

[Edited on 30-7-2020 by fdnjj6]

fdnjj6 - 29-7-2020 at 23:20

Also I hope that the fact that I right away asked about benzocaine's synthesis, which I knew had 0 narcotic effects, is a sign of me not giving a shit about the actual effects. I was mainly choosing these chemicals due to their relative ease of synthesis. I still don't believe I could pull off the propofol synthesis but I have my notebook filled with notes and plans for the benzocaine synthesis because it is exactly what I was looking for. An awesome multistep synthesis. I am sourcing my toluene from carb cleaner so how cool is it to know you made a modern weak anesthetic from freaking carb cleaner?

To me that is just amazing and will hopefully be a way to see how good of a chemist I am. I suspect I will have lots of trouble with the whole synthesis but I think thinking things through, planning, and lots of research and help from sites like these will help me achieve my goal.

fdnjj6 - 30-7-2020 at 01:05

I'd also like to thank Fery, I just read the book that he sent and it contains very good information. The initial synthesis I was going to use would have created issue for isolating the p-aminobenzoic acid due to only neutral conditions being where it is insoluble. I will have to follow a different route which the book mentions. I'll also have a look at the other chemicals that could be made. Thank you.

[Edited on 30-7-2020 by fdnjj6]

fdnjj6 - 30-7-2020 at 01:15

Forget what I said. The HCl/Zn reduction is part of the synthesis mentioned so I was wrong.

The benzocaine structure is still wrong though as it has a nitro group instead of the amine group.

Is reduction via CaCl2, 95% ethanol, and Zn powder something that is actually easily reproduced?

Step-III. Reduction of Ethyl p-Nitrobenzoate.
(1) Transfer 1 g of calcium chloride in 12 ml of water placed in a 100 ml beaker ; and mix
this solution with 55 ml of 95% (v/v) ethanol.
(2) Pour the resulting solution into a 250 ml round bottom flask that contains 2.5 g (0.013
mol) of ethyl p-nitrobenzoate (Step-II), add to it 25 g of Zn-dust, and attach to it a
reflux condenser.
(3) Reflux the reaction mixture for 2 hours gently and at a stretch and then cool to room
temperature.
(4) Separate the unreacted Zn-dust from the aqueous ethanolic solution in Büchner funnel under suction, and wash the filtered solid with two 25 ml portions of solvent
ether.
(5) Extract the filtrate with 150 ml of water previously saturated with NaCl. Wash the
aqueous layer twice with 25 ml portions of solvent ether. Combine all the ethereal
layers together (including one obtained in (4) above ; and wash it with two successive
portions each of 40 ml of water.
(6) Dry the resulting ethereal solution over anhydrous Mg SO4, filter, and subsequently
distil the ether on a steam bath to a final volume of 10 to 15 ml. Transfer the ethereal
residue to an Erlenmeyer flask and add to it 20 ml of pentane to precipitate the
desired product benzocaine.
The yield of the crude benzocaine is 1.58 g having mp 88-89.5°C.

It seems like it worked for them but I have never heard of such a reduction before.

[Edited on 30-7-2020 by fdnjj6]

fdnjj6 - 30-7-2020 at 02:40

Shit, don't forget what I said. The reaction calls for dilute acetic acid but it's never added! Wtf kind of a book is this?? Multiple things already wrong and I only looked at one reaction so far.

Fery - 30-7-2020 at 11:26

If you are able to obtain lidocaine, you can synthesize denatonium from it, the most bitter substance yet known (you won't be able to feed yourself with your own hands for a lot of days without tasting that nasty compound). Though it is usually easier to buy denatonium saccharide/benzoate than lidocaine.

[Edited on 30-7-2020 by Fery]

fdnjj6 - 30-7-2020 at 20:22

I have seen NileRed make that stuff and I'd rather not. He was playing cards with some friends a few days after making the stuff with copious hand washing, and one of his friends ended up with a bitter taste in his mouth from him. Screw that haha.

I have ultimately decided on making benzocaine. It will be difficult for me as I know the theory but this will be the first time I do such reactions in a practical manner. To most, the synthesis is probably trivial but I was already a bit stressed out because I couldn't figure some things out. The text book I was given by someone in this thread has lots of false information and many synthesis are written terribly and are missing reagents. Maybe I am missing something but I don't want to follow it. The current synthesis scheme I am going to go for is toluene --> nitrotoluene --> p-nitrotoluene --> p-nitrobenzoic acid --> p-aminobenzoic acid --> ethyl p-aminobenzoate which is the benzocaine I am going for.

The mono nitration already gives me some issues. I don't have concentrated nitric acid but I made dilute nitric acid which is assumed to be 40-50% and while I need to do a crude titration of it, I think it will work since I did the math to get the ratios of acids and water to the proper percentages for mono nitration. I see people make some of their mononitrotoluene baths up to 50C though! I'm going to stay below 20C since I want 0 dinitrated product. While I have easily done many tri and tetra nitrations, I was able to just dump a nitrate salt into sulfuric acid and call it good. I could possibly do the same thing here but I don't really know how well a nitrate salt for toluene. I assume it'd be fine if I drip the acid onto some water to dilute it to approximate ratios but I'm not sure. I may do a test tube scale nitration test to see if I get proper products. Then again, making more toluene isn't too much of an issue for me. I currently have a little bit I extracted from carb cleaner but I may extract another can to make sure I can have as many nitration attempts as possible. Separation of para isomer is seemingly easy since I just need to chill the crude oily product to below -10C and then the p-nitrotoluene should crystallize out. Vacuum filter and recrystallize.

Then, the next part. The oxidation of p-nitrotoluene. I was going to use potassium dichromate but after reading the msds I quickly cancelled that. The oxidation is cleaner and likely easier to separate the product, but my god the toxicity is too much for me to want to handle. So I am using KMnO4 in acidic conditions. It's more messy but worth not giving myself cancer and dealing with even worse hazardous waste. So I'll try to oxidize the methyl group of toluene using KMnO4 to make p-nitrobenzoic acid. I'll add a solution of KMnO4 to the p-nitrotoluene and sulfuric acid, and reflux until the reaction is complete. I think I will try to use the KMnO4 as the limiting reactant so that I don't have leftover KMnO4. If I do have leftover KMnO4 I could just add some bisulfate until colorless correct? One thing I don't know is whether the p-nitrobenzoic acid will form a salt with the potassium ions. That should make it water soluble and I can just filter off the MnO2 and then precipitate the p-nitrobenzoic acid by deprotonating it with sodium hydroxide solution. If it decides to not form a salt and just precipitates out, I can filter and wash with water. Then the MnO2 and p-nitrobenzoic acid is separated by dissolving the p-nitrobenzoic acid in acetone, leaving the insoluble MnO2 behind.

The next and possibly most difficult step (according to the book I was given that had the inaccurate info in it) is reducing the nitro group to an amine. I'll use tin that I try to get as thin and small as possible with HCl. I found a paper that documents the whole process so I am not too worried anymore about failing that step. Isolating the p-aminobenzoic acid is the hard part according to the book, but it seems like the paper I have gets it right. I cross referenced it to other papers I managed to dig up and the isolation of product is practically identical. Add ammonia solution until the pH is around 8, filter the tin salt precipitate, concentrate by steam bath evaporation, and then adding a small amount of glacial acetic acid until the pH is about 3. Then cool the solution and the p-aminobenzoic acid should precipitate.

The last step I haven't researched too much but I know it should be the easiest step of them all. Fischer esterification with sulfuric acid and ethanol. There are many videos on Youtube alone showing this step so I am confident this won't be an issue.

If all goes well, I should now have relatively pure ethyl p-aminobenzoate aka benzocaine. I'll test the melting point and hopefully it is near theoretical. I'll test as many ways as possible to make sure I have the actual product. If I do I will be so ecstatic knowing I just pulled off my first multi step organic synthesis.

Does the above reaction plan sound good? I am super pessimistic and feel like I will fail at everything so I am really wanting to make sure I'm not about to become really frustrated over nothing.

thors.lab - 3-8-2020 at 01:08

Quote: Originally posted by fdnjj6  
I was going to prepare acetaminophen but guess who doesn't have the balls to make acetic anhydride? This guy.
[Edited on 30-7-2020 by fdnjj6]


Hahah this is why I gave up on my synthesis as well.

thors.lab - 3-8-2020 at 01:16

Quote: Originally posted by fdnjj6  

The mono nitration already gives me some issues. I don't have concentrated nitric acid but I made dilute nitric acid which is assumed to be 40-50% and while I need to do a crude titration of it, I think it will work since I did the math to get the ratios of acids and water to the proper percentages for mono nitration. I see people make some of their mononitrotoluene baths up to 50C though! I'm going to stay below 20C since I want 0 dinitrated product. While I have easily done many tri and tetra nitrations, I was able to just dump a nitrate salt into sulfuric acid and call it good. I could possibly do the same thing here but I don't really know how well a nitrate salt for toluene. I assume it'd be fine if I drip the acid onto some water to dilute it to approximate ratios but I'm not sure. I may do a test tube scale nitration test to see if I get proper products. Then again, making more toluene isn't too much of an issue for me. I currently have a little bit I extracted from carb cleaner but I may extract another can to make sure I can have as many nitration attempts as possible. Separation of para isomer is seemingly easy since I just need to chill the crude oily product to below -10C and then the p-nitrotoluene should crystallize out. Vacuum filter and recrystallize.


I don't think nitration of toluene should pose an issue. I assume it would be similar to the nitration of benzene. NileRed has a video on it, as do I. If you don't have 68% nitric acid, it's pretty damn quick and easy to make (there are dozens on YouTube, I also have a video on that myself).

Source on the separation of p-nitrotoluene? Can't seem to find anything on that. I might try it out myself.

njl - 3-8-2020 at 03:41

@toms lab https://pubchem.ncbi.nlm.nih.gov/compound/4-Nitrotoluene#:~:... check the freezing point. Also do you happen to have a youtube channel?

thors.lab - 3-8-2020 at 04:08

Quote: Originally posted by njl  
@toms lab https://pubchem.ncbi.nlm.nih.gov/compound/4-Nitrotoluene#:~:... check the freezing point. Also do you happen to have a youtube channel?


I don't see Tom's lab in this thread so maybe you're talking about me (Thor's lab). Yeah I do have a YouTube channel, it's in my signature :) Tom's lab is great too, he's also on YouTube!

MP of 4-nitrotoluene is 50ishºC. You said we need to chill to -10ºC. Just wondering where you get that figure from?

Tsjerk - 3-8-2020 at 04:40

Separation of p-nitrotoluene from o-nitrotoluene is easy, it freezes out nicely from the ortho in any freezer, just go as low as your freezer goes. I don't know what happens if you go below -20, but even at that temperature the ortho won't freeze. I suspect the contamination of the para causes freezing point lowering of the ortho. But as far as I can tell the para that freezes out is as pure as you can wash/suck the ortho off.

fdnjj6 - 3-8-2020 at 22:04

Yea so the thing is I'm not putting that in my freezer. I will cool the isomer mix in an ice bath, then cool a 20-24% NaCl solution to -20C and then use that solution to precipitate the isomers. The papers I found use -20C with good separation. I have a ghettoish vacuum filtration set up that should work to filter everything quickly. The only thing I didn't understand/like is that the ortho freezes at around -10C so I assume the isomers form a eutectic mix and that the para product ppt first. Once I perform the reactions I will test the melting point of the solid product The ortho and para have a pretty separate melting point so I'll know if I have my product. Making conc. nitric acid is very easy but I really don't like distilling acids. I need to run some test on the dilute acid I have and if it is at least 40% it is usable. I'll have to up the sulfuric acid amount to match the ratios from patents to get decent yields. I'm assuming my acid is 50% but titration will tell. I am waiting on a thermometer piece until I proceed with fractional distillation of toluene and the subsequent steps.

fdnjj6 - 3-8-2020 at 22:06

Oh I got that number since the freezing point of ortho is around -10C. Since this should be fractional crystallization I assumed that would work. According to papers I found they all mention -20C to be the temp to aim for. I'll get as close as possible. Then I'll vacuum filter and recrystallize the solid. Small sample gets a MP check and then if it is reasonably pure I move on to the rest of the synthesis.

thors.lab - 3-8-2020 at 23:55

Quote: Originally posted by fdnjj6  
Yea so the thing is I'm not putting that in my freezer. I will cool the isomer mix in an ice bath, then cool a 20-24% NaCl solution to -20C and then use that solution to precipitate the isomers. The papers I found use -20C with good separation. I have a ghettoish vacuum filtration set up that should work to filter everything quickly. The only thing I didn't understand/like is that the ortho freezes at around -10C so I assume the isomers form a eutectic mix and that the para product ppt first. Once I perform the reactions I will test the melting point of the solid product The ortho and para have a pretty separate melting point so I'll know if I have my product. Making conc. nitric acid is very easy but I really don't like distilling acids. I need to run some test on the dilute acid I have and if it is at least 40% it is usable. I'll have to up the sulfuric acid amount to match the ratios from patents to get decent yields. I'm assuming my acid is 50% but titration will tell. I am waiting on a thermometer piece until I proceed with fractional distillation of toluene and the subsequent steps.


I appreciate your caution but I think you might be being a little overly cautious. Nitric acid distillation is pretty easy and not as bad as sulfuric acid because the temperatures involved are much more reasonable (120ºC compared to like 300). I also don't think a bit of nitrotoluene in your freezer is going to be a big deal if its inside a container with something covering it. 4 nitrotoluene vapor pressure is gonna be super low at that temperature (like less than 0.015 kPa, compared to benzene at like 10kPa). The vapor is also denser than air so it will sink and stay in the container.

That being said if you have the patience to avoid all of that then that's definitely the way to go haha.

thors.lab - 4-8-2020 at 00:02

Quote: Originally posted by fdnjj6  
Oh I got that number since the freezing point of ortho is around -10C. Since this should be fractional crystallization I assumed that would work. According to papers I found they all mention -20C to be the temp to aim for. I'll get as close as possible. Then I'll vacuum filter and recrystallize the solid. Small sample gets a MP check and then if it is reasonably pure I move on to the rest of the synthesis.


How are you doing MP check? I've been wanting to get a way to do that in my lab. I don't trust those cheap ass spirit thermometer based ones.

Side note: I think I want to upgrade to a heating mantle rather than a hot plate since I'm getting pretty sick of oil baths. Any affordable recommendations? Looking at this cheap ass $150 amazon 500mL one from Faithful but I'm not so sure I trust it. Or maybe the even cheaper analog heating one.

fdnjj6 - 4-8-2020 at 02:40

Yea I am definitely a overcautious. I am 99% sure I could just place the stuff in my freezer and call it good. However, that just doesn't sit right with me. Chemicals should go nowhere near food so I'd rather do the extra work than gamble on the 1% chance that something goes wrong. I could have the p-nitrotoluene crystallize out a lot and expand, cracking the glass and leaking nitrotoluene everywhere. Just something I'd rather not do.

I also don't want to distill acids anymore. I have distilled nitric acid before but it just scares me too much at this point and if you are working with fear in you mind, you are bound to make mistakes. Once the rest of my lab equipment finally arrives I'll be able to properly titrate the nitric acid. It should be around 50%. Also storing it dilute is safer and fumes much less. I used to be *heavily* into explosive chemistry and I still didn't dare distill fuming nitric acid. I always made it in situ and just kept my dilute acid for dissolving metals. At some point I'll run out but it should be a while.

I figured out the ratios needed for mono nitration and like I said 40-50% should work just fine. It might even yield better since less target product is reacted into dinitrotoluenes. Not sure though.

As far as the melting point thing goes, I will just allow the crystals to warm up to room temp. Once they warm up, if they melt between 0-30C I know it's heavily contaminated. If it melts at around 50C I'll be good to move on. I'll likely just use a test tube with a thermometer in a water bath that is slowly raised to a higher and higher temp. Once the sample melts, I'll begin recording the temps. The readings will not be very accurate at all but will give me a good idea if I have my target product. I think if you can get some capillary tubes and put them in an oil bath and observe the sample, you can probably get more accurate results but I'm not sure how close you can get to proper machines doing the work.

Tsjerk - 4-8-2020 at 03:36

Rule of the tumb: in an amateur setting you only have to worry about water, bismuth and gallium expanding when freezing. The rest shrinks. That is a good thing because otherwise a lot of glacial acetic acid spills would occur.

zed - 9-8-2020 at 17:55

Forum rules? Scientific discussions are OK. Not supposed to be a "Cooking" forum.

I'll pretty much discuss anything. I just assume you are in an academic environment, or have a permit, or...the material in question isn't regulated in your jurisdiction.

Otherwise, it is to the reformatory, that you may be a-going.

Heh, heh. Propofol, iced Michael Jackson, and possibly Brittany Murphy too! Final Exit stuff.

Why not Viagra? More life affirming! And probably, as long as you don't sell it, nobody cares.

Nope! Viagra looked like a pain in the ass.

Cialis! Cialis, is doable. Especially if the dimethoxy analog is active.
https://www.sciencedirect.com/science/article/abs/pii/S09574...

Um. Better check that.

Yeah, not sure of activity, but Veratraldehyde is more easily synthesized or acquired, than Piperonal.

Tryptophan is cheap and available. Fun project.

https://en.wikipedia.org/wiki/Tadalafil

The 3,4-Methylenedioxy substituent, may be replaced by other groups. But I haven't been able to find an extensive list. 3,4-Dimethoxy, would figure to be active, but I can't find data.



[Edited on 10-8-2020 by zed]

fdnjj6 - 10-8-2020 at 16:02

Quote: Originally posted by zed  
Forum rules? Scientific discussions are OK. Not supposed to be a "Cooking" forum.

I'll pretty much discuss anything. I just assume you are in an academic environment, or have a permit, or...the material in question isn't regulated in your jurisdiction.

Otherwise, it is to the reformatory, that you may be a-going.

Heh, heh. Propofol, iced Michael Jackson, and possibly Brittany Murphy too! Final Exit stuff.

Why not Viagra? More life affirming! And probably, as long as you don't sell it, nobody cares.

Nope! Viagra looked like a pain in the ass.

Cialis! Cialis, is doable. Especially if the dimethoxy analog is active.
https://www.sciencedirect.com/science/article/abs/pii/S09574...

Um. Better check that.

Yeah, not sure of activity, but Veratraldehyde is more easily synthesized or acquired, than Piperonal.

Tryptophan is cheap and available. Fun project.

https://en.wikipedia.org/wiki/Tadalafil

The 3,4-Methylenedioxy substituent, may be replaced by other groups. But I haven't been able to find an extensive list. 3,4-Dimethoxy, would figure to be active, but I can't find data.



[Edited on 10-8-2020 by zed]


? benzocaine and nitric acid are not illegal or a "cooking" type thing... I'm not sure what you mean. I was literally looking for just a good project to test my skills. Why would I choose benzocaine which has absolutely 0 pleasant effects? It's literally just a local anesthetic and is sold all over the place.

I've already finished the extraction of toluene and the nitration. I just need to dry the isomer mix now and separate the isomers. Should be easy but very toxic so it takes a lot of time and effort to plan everything out to go smoothly. The nitration I did was highly detailed and I still had some spills and mishaps. All is well though.

I didn't ask for "cooking" help, I just wanted some medicinal multi step projects. I have thymolphthalein and other synthesis lined up, but wanted something different.

So far through this project I have already learned LOADS of stuff and it's pretty fun. Once the p-nitrotoluene is oxidized into p-nitrobenzoic acid, the toxicity for the whole rest of the synthesis also is basically normal. I don't like the cancerous and toxic nature of the nitrotoluene so the next steps will be much more fun since I don't have to worry about giving myself cancer anymore. Although I don't have to anyway since I wore a proper respirator, had a fan, did it outside, used an almost completely closed reaction vessel, went through about 8 pairs of gloves, had two layers of full body covering, and was only able to smell the nitrotoluene a few times for only a couple (2-5) seconds. So given the minimal exposure and high safety in place, I think I'm fine. I can't wait for the benzocaine haha. I will have made a modern local anesthetic from a $2 carb cleaner bottle. That's assuming everything will go right and I get decent yields though. Wish me luck!

fdnjj6 - 10-8-2020 at 16:05

I also didn't know propofol had such effects. I was still researching and looking for new projects to do and the structure seemed like something I could achieve. The synthesis ended up being something I might have been able to pull off but I felt it was still a bit out of reach. As far as I knew, propofol isn't illegal to make or possess where I live. I didn't look into it much as I was still just making a list of doable synthesis that weren't obviously illegal like methamphetamine, quaalude, or MDMA.

Thanks for the recommendation! The structure looks quite intimidating though.

Herr Haber - 14-8-2020 at 08:35

Seing your earlier use of German I'll assume you are either in Germany or Austria.

If so, possession of nitric acid is and has been illegal for several years now. It doesnt matter if you make it or buy it.
Propofol is an anesthetic. You didnt think this would be a regulated substance well... I cant help you there.

karlos³ - 14-8-2020 at 10:01

I know for certain that propofol isn't "regulated", when we assume the usual meaning of that means it is a controlled drug.
Precisely, it doesn't fall under any of the drug law categories, however it does of course under the pharmaceutical drug law, just like anything else that is used for humans.

The reason I know this exactly is, that I've read an article about how this lack of regulation and consequently no strict inventory control in the hospital depots, is said to be the most important factor that resulted in doctor, mostly the anesthetists with access and knowledge about its use, to abuse this stuff, shockingly often even.

However, now with the OP having snapped, I would strongly disadvise against him trying to make anything stronger than aspirin!
But for the record, as I know the field of "synthesis of medical organic molecules" quite well, even if I would never call it like this, I know there are much better target molecules, many of them uncontrolled, most of them quite simple to make, and definitely something that promises fun for responsible adults.
But all of them are definitely nothing that belongs into the hands of too young adults.

Aspirin as said.
That is a good target compound, harmless and absolutely not promising fun.
I would recommend making this to the OP.

fdnjj6 - 14-8-2020 at 11:49

Quote: Originally posted by Herr Haber  
Seing your earlier use of German I'll assume you are either in Germany or Austria.

If so, possession of nitric acid is and has been illegal for several years now. It doesnt matter if you make it or buy it.
Propofol is an anesthetic. You didnt think this would be a regulated substance well... I cant help you there.


Not in any of those countries. I don't make nitric acid anymore though.

I don't think it's necessarily illegal to own or make nitric acid in Germany, it is regulated and I believe illegal to sell though.

Also things like chloroform and chlorobutanol are also anesthetics and not regulated or illegal at all. Granted, a bit different but nonetheless still not regulated.

Just because something is regulated doesn't mean it can't be discussed here. If something is illegal to own or make that's different but I mean explosives, things like o-toluidine, acetic anhydride, are all HIGHLY regulated and discussion is still allowed. I don't think propofol is a scheduled substance (at least where I live) and so I figured no harm is done.

[Edited on 14-8-2020 by fdnjj6]

fdnjj6 - 14-8-2020 at 12:04

Quote: Originally posted by karlos³  
I know for certain that propofol isn't "regulated", when we assume the usual meaning of that means it is a controlled drug.
Precisely, it doesn't fall under any of the drug law categories, however it does of course under the pharmaceutical drug law, just like anything else that is used for humans.

The reason I know this exactly is, that I've read an article about how this lack of regulation and consequently no strict inventory control in the hospital depots, is said to be the most important factor that resulted in doctor, mostly the anesthetists with access and knowledge about its use, to abuse this stuff, shockingly often even.

However, now with the OP having snapped, I would strongly disadvise against him trying to make anything stronger than aspirin!
But for the record, as I know the field of "synthesis of medical organic molecules" quite well, even if I would never call it like this, I know there are much better target molecules, many of them uncontrolled, most of them quite simple to make, and definitely something that promises fun for responsible adults.
But all of them are definitely nothing that belongs into the hands of too young adults.

Aspirin as said.
That is a good target compound, harmless and absolutely not promising fun.
I would recommend making this to the OP.


You know I've calmed down quite a bit and I'll admit I took things a bit too personally in that post (life's not the best right now, at all actually, which is why I'm trying to get into more challenging chem to take my mind off of it), however, the post in question wasn't even targeted towards you since you claim to have good safety, fume hood, etc. (at least I think you said that) and the post was directed towards people who thought they were doing things safely like me. There's a large misconception that doing things outside is exactly the same as having a fume hood. The words are often used interchangeably in many amateur Youtube videos.

While I am not a child or kid, (the nitric acid happened ages ago and the nitrotoluene wasn't something I even knew about as a kid minus TNT) and I do have the skills and most of the equipment to do advanced organic chemistry, I just don't have the right setting to do it. I can and have kept myself safe for the entire 6 years of amateur chemistry. I started safe and easy for the first years, then explosive chem, and now organic chem. I never as much got an acid burn. Maybe a thermal burn from a hot plate but I was always unharmed.

My post was regarding the safety of others around you and seeing how I was torn apart for trying to help people out and not have them make the same mistakes as me, I was (in my eyes) relatively justified to be outraged a bit. Like I said I took it too far and actually U2Ued the mods to just ban my account because I was so pissed seeing how people just seem to not give a fuck about the people around them. I was thinking of never even looking back on this website. I don't know if I still want to just leave the website as a whole as I can still post some reports of the chemistry I am still doing (like I said amateur chem is still something I think should definitely stay around, just the stuff at home how most amateurs run it should be kept at safe chem).

Funnily enough aspirin is the only chemical that put me in the emergency room. Wasn't doing chemistry but my body seemed to not like it.

But I am able to synthesize things and can handle advanced things. I've got one semi advanced synthesis lined up for benzoic acid esters from carb cleaner (toluene extraction), a biodiesel synthesis (just for shits and giggles and trying to maximize yield), chlorobutanol ( I realized chloroform is something that is acceptable even at home), possibly isopropyl nitrite, thymolphthalein, methyl anthranilate from xylene isomer mix, solvent preparation, and some titrations that need to be done.

So I'm not done, still a bit disappointed, but definitely took things too personally. Not sure if the mods will still ban me since I practically begged them to. Guess I'll find out.

[Edited on 14-8-2020 by fdnjj6]

fdnjj6 - 14-8-2020 at 12:20

Quote: Originally posted by karlos³  
I know for certain that propofol isn't "regulated", when we assume the usual meaning of that means it is a controlled drug.
Precisely, it doesn't fall under any of the drug law categories, however it does of course under the pharmaceutical drug law, just like anything else that is used for humans.

The reason I know this exactly is, that I've read an article about how this lack of regulation and consequently no strict inventory control in the hospital depots, is said to be the most important factor that resulted in doctor, mostly the anesthetists with access and knowledge about its use, to abuse this stuff, shockingly often even.

However, now with the OP having snapped, I would strongly disadvise against him trying to make anything stronger than aspirin!
But for the record, as I know the field of "synthesis of medical organic molecules" quite well, even if I would never call it like this, I know there are much better target molecules, many of them uncontrolled, most of them quite simple to make, and definitely something that promises fun for responsible adults.
But all of them are definitely nothing that belongs into the hands of too young adults.

Aspirin as said.
That is a good target compound, harmless and absolutely not promising fun.
I would recommend making this to the OP.


Also, while I'm sure you'll probably still doubt it, what I said was true. It wasn't some made up lie. Why would I lie about that?

I work at night so people don't see my hazmat suit and glassware and call the cops (I had a sheriff slowly drive by once with his spotlight looking for someone, but they were looking for a missing person and not me haha), and also since the weather is typically much more calmer at night. That night was damn near wind still and since I was working with the nitrotoluene isomer mix for a few hours failing to get proper separation (I got probably 500mg or p-nitrotoluene since I didn't have a prechilled vacuum filtration system, I have one but seeing what the nitrotoluene did to my storage bottle lid, I didn't want it to ruin my pump) and add on top of that that nitrotoluene has a very low odor threshold and very distinct (to me a cherry like odor, people say almond but it smells like cherries to me) smell, I think that is why my family member was able to smell it. They do tend to freak out though but justifiably so but even after I lied and said that it was all non toxic they calmed down but still complained of a burning sensation which matches the irritation potential that nitrotoluenes have. So it wasn't at a negligible concentration anymore. I had exposed myself to some of the fumes and had nothing. But after I was exposed to a very low concentration for 2 days (low enough to not even smell) I had a fruity metallic taste in my mouth and a bit of a weird feeling in my head.

arkoma - 14-8-2020 at 13:05

THIS WRITEUP by one of the "OG" members of this site (Magpie RIP) should put to rest this crap that discussion of "drug chemistry" is verboten here. It's all in the context. Yeah, maybe someone here makes benzaldehyde (a DEA List 1 precursor) so they can use it as almond flavoring but I really doubt it.


*EDIT* A quote from Polverones "Mad Science FAQ's"
Quote:
Do not request spoonfeeding of information for clandestine drug manufacture. However, every sort of chemistry is a permissible topic of discussion if you discuss it like a scientist.


[Edited on 8-14-2020 by arkoma]

fdnjj6 - 14-8-2020 at 14:55

Quote: Originally posted by arkoma  
THIS WRITEUP by one of the "OG" members of this site (Magpie RIP) should put to rest this crap that discussion of "drug chemistry" is verboten here. It's all in the context. Yeah, maybe someone here makes benzaldehyde (a DEA List 1 precursor) so they can use it as almond flavoring but I really doubt it.


*EDIT* A quote from Polverones "Mad Science FAQ's"

Quote:
Do not request spoonfeeding of information for clandestine drug manufacture. However, every sort of chemistry is a permissible topic of discussion if you discuss it like a scientist.


[Edited on 8-14-2020 by arkoma]


Thank you. I find the spectrum of sensitivity on this site quite weird. Some people straight up admit to exposing others with chemical fumes and they don't care. Others get rotten if there is a hint of a possible drug precursor involved. In this case nothing illegal at any point which I clearly made crystal clear in the original post.

fdnjj6 - 14-8-2020 at 23:51

Quote: Originally posted by karlos³  

However, now with the OP having snapped, I would strongly disadvise against him trying to make anything stronger than aspirin!
But for the record, as I know the field of "synthesis of medical organic molecules" quite well, even if I would never call it like this, I know there are much better target molecules, many of them uncontrolled, most of them quite simple to make, and definitely something that promises fun for responsible adults.
But all of them are definitely nothing that belongs into the hands of too young adults.

Aspirin as said.
That is a good target compound, harmless and absolutely not promising fun.
I would recommend making this to the OP.


Quicksilver's reply under someone making a remotely meh comment towards a guy who ended up in the ER for mishandling ETN (I used to make this stuff and learned from him to not heat that shit even if tempted, I learned quite a lot from people through them sharing their mistakes actually).

Here is what he had to say:

It's inappropriate to call someone names who has the courage of his convictions in displaying his mistakes.

When someone admits he has made a mistake and put that "on front street" it's obvious that he is doing so to show how dangerous something can be. This is NOT typical! Typically the injured individual slinks away and never communicates again.

If you would like to see just how fucking angry I can get - just call this man names.
Anymore name-calling & there will be problems.....I hope that is DAMN CLEAR.
His actions were ill thought out and he knew it yet he made extreme errors in judgement. He also was honest enough to publicly display his mistakes to benefit those who may mis-judge experiments with energetics. His honestly is commendable; his judgment was not....PERIOD!
Name calling in this instance makes me seriously angry. Gentlemen; to sit on the sidelines (and do so) is NOT science.

ONE mis-calculation with energetic materials can be enough to loose eyes, fingers/hands, genitals, etc. It HAPPENS - SO OFTEN that the majority here don't realize it.
One of the major thrusts of this forum is learning science and NOT practical applications. Lab safety cannot be stressed too much BECAUSE we eventually become lax.
Sometime back I discussed the concept of NEVER working with materials if you feel the least bit "off" that day. If your mind is elsewhere, if you are pre-occupied, or tired - whatever. I would be willing to BET GOOD MONEY that everything I had outlined the OP knew.

This is very important thread. The issues were containment, particle size/weight, stimulus, and proximity. IF you gentlemen are going to discuss this in elements of science then do so. And do so with the knowledge that the OP put himself out there for potential ridicule to PREVENT this from happening to others. However I will NOT allow this man to be ridiculed & I hope that is damn clear!

The MOMENT you think this can't happen to you is the very moment that it can! That is one of the first things taught in a variety of professional settings, so let it also be known here as well.



Looks like I'm not the only one who would've/did snap on someone ridiculing a person sharing their mistakes. Quicksilver is well respected on SM and seeing how I was treated by you and the mods, I feel a hint of irony in all of this.

I know I should be over it by now but I figured I'd show you that I'm not some dumbass kewl who snaps at everything (which by looking at the post you just put out for everyone to see, it sure as hell sounds like you think of me like that). Plus the post wasn't even aimed at you and your "safe lab" so there was no reason to act how you did. Thanks to you and your ridiculing, calling me a sissy, liar, attention whore, etc. for sharing my mistakes which I hoped others could learn from, and promoted safe chemistry for people who don't have the proper fume hoods and filters, you instead got the whole thread moved to detritus for less people to see. So thanks for that man. Really blows when people like you show up.

[Edited on 15-8-2020 by fdnjj6]

[Edited on 15-8-2020 by fdnjj6]

draculic acid69 - 15-8-2020 at 03:42

Quote: Originally posted by Syn the Sizer  
[rquote=641757&t
I had no idea tert-amyl alcohol was a recreational product. I had always though the only alcohol we could consume without hurting ourselves severely was ethanol.


I think there are 2other alcohols you can drink that have effect and aren't deadly.
I think ones got a vinyl group in there somewhere

Tsjerk - 15-8-2020 at 05:41

You don't have to use caps lock in English. That is only done in German. It looks like you are shouting.

fdnjj6 - 15-8-2020 at 13:08

Quote: Originally posted by Tsjerk  
You don't have to use caps lock in English. That is only done in German. It looks like you are shouting.


The caps lock was from Quicksilver's reply... not mine.

Chemi Pharma - 15-8-2020 at 13:46

I suggest you @fdnjj6 to take a look at The Drug Classroom Channel videos at You Tube (link here: https://www.youtube.com/c/TheDrugClassroom/videos). The guy explain very well about pharmaceuticals, show the chemical formula, effects, dosage, uses, misuses. Then, when you find some drug that you have interest and think the chemical formula isn't too complicated you do a google search to find patents, studies and researches about the synthesis and retro synthesis steps. It's what I usually do at my Lab as my hobby and I have some interesting projects in mind about this subject. If you want to discuss more about pharmaceutical drugs synthesis in private, feel free to call me at U2U.

Tsjerk - 15-8-2020 at 14:01

Quote: Originally posted by fdnjj6  
Quote: Originally posted by Tsjerk  
You don't have to use caps lock in English. That is only done in German. It looks like you are shouting.


The caps lock was from Quicksilver's reply... not mine.


I meant the words you wrote in BOLD. Only Germans do that

draculic acid69 - 15-8-2020 at 18:35

What about following nurdrages example of making daraprim? Doable and non psychoactive

thors.lab - 19-8-2020 at 23:02

Quote: Originally posted by Herr Haber  
Seing your earlier use of German I'll assume you are either in Germany or Austria.

If so, possession of nitric acid is and has been illegal for several years now. It doesnt matter if you make it or buy it.
Propofol is an anesthetic. You didnt think this would be a regulated substance well... I cant help you there.


Are you really going to rag on this guy for having nitric acid? Next I suppose you'll tell me I'm satan for importing Naphtha into California :o

aromaticfanatic - 22-8-2020 at 11:28

Quote: Originally posted by Tsjerk  
Quote: Originally posted by fdnjj6  
Quote: Originally posted by Tsjerk  
You don't have to use caps lock in English. That is only done in German. It looks like you are shouting.


The caps lock was from Quicksilver's reply... not mine.


I meant the words you wrote in BOLD. Only Germans do that


What the hell is your issue? He literally said it was from Quicksilver's reply. THIS is not bold btw, that is caps lock.

And not just done in German.

[Edited on 22-8-2020 by aromaticfanatic]

aromaticfanatic - 22-8-2020 at 11:45

Quote: Originally posted by thors.lab  
Quote: Originally posted by Herr Haber  
Seing your earlier use of German I'll assume you are either in Germany or Austria.

If so, possession of nitric acid is and has been illegal for several years now. It doesnt matter if you make it or buy it.
Propofol is an anesthetic. You didnt think this would be a regulated substance well... I cant help you there.


Are you really going to rag on this guy for having nitric acid? Next I suppose you'll tell me I'm satan for importing Naphtha into California :o



I know right. It's not even illegal according to the German laws on Google. He makes it seem like the energetics forum doesn't exist haha.

karlos³ - 22-8-2020 at 12:46

Herr Haber made fun of the anal retentive thinking of the OP, thats all.
Its German humour, you wouldn't get it :P

aromaticfanatic - 23-8-2020 at 00:26

Quote: Originally posted by karlos³  

Its German humour, you wouldn't get it :P


No I would... I am German. Soll ich es Pruefen? Ich wohne aber nicht in Deutschland. Ich bin in einem anderen Land haha. War OP Deutsch oder warum wurde er direkt als Deutsch anerkannt? I do get it though but the delivery wasn't exactly funny more than it was kind of a dick move.

Translation:
I am German. Shall I prove it? I don't live in Germany though. I am in a different country haha. Is OP German or why did everyone label him as German?

Tsjerk - 23-8-2020 at 02:07

Ok... Read capitalized where I wrote bold.

OP is German AF, but was only "practicing" his German when he was told to write English on an English forum.