Sciencemadness Discussion Board

Got my own NMR

Bmoore55 - 22-4-2020 at 17:37

So I had an amazing eBay acquisition and got an 80 MHz bench top nmr. I am so excited and I just wanted to share the first crap spectrum haha.

71D33770-5900-4306-89C0-2BC24DA5FEFB.jpeg - 3.5MB

DraconicAcid - 22-4-2020 at 17:46

You got that on eBay?????!!???!?!? Seriously?

Congratulations on an amazing acquisition!

Bmoore55 - 22-4-2020 at 18:24

Thanks! I couldn’t believe it, but I got it and sent it in for repairs. Just got it back two days ago. I’m trying to decide what I want to run on it haha.

Bmoore55 - 22-4-2020 at 18:57

Oh by the way it’s a Thermo Picospin 80, so it’s an 80 MHz bentchtop NMR that only does 1D proton NMR experiments.

BromicAcid - 22-4-2020 at 19:23

The Picospin is kinda neat since you don't need NMR tubes for it. Hope you have some fun!

Texium - 22-4-2020 at 20:13

Wow, that’s amazing! You must have gotten an amazing deal (or dropped a small fortune).

Side note: your spectrum would look less crappy if you integrated the CH as your 1 instead of the OH ;)

outer_limits - 22-4-2020 at 20:18

Have fun :)

reactofurnace - 22-4-2020 at 22:25

Ohhh dang nicee!!

j_sum1 - 23-4-2020 at 01:58

I am sure that I have no real appreciation of just how awesome this is.

Congratulations. This is seriously cool.

AgCollector - 23-4-2020 at 03:41

Looks great! Nice find.

Bmoore55 - 23-4-2020 at 07:47

I got it for a crazy good price, practically a steal. I am running samples on it right now!

Bmoore55 - 23-4-2020 at 15:52

I have been on the lookout for one of these for several years now and I was so amazed I got one. I will include this in my next video for sure.

monolithic - 23-4-2020 at 17:38

That's incredible. Nice find.

HeYBrO - 23-4-2020 at 18:24

Awesome, I'm very jealous. I did a quick look, anyone with about $3500 USD to spare there is a pickospin 45 on eBay right now

Dr.Bob - 23-4-2020 at 18:44

That is an amazing deal. I have a similar situation at work, where we have several NMRs and almost no one working, so no lines, queues, or waits in most cases. But cost more than that just to keep full of cryogens.

Heptylene - 24-4-2020 at 00:42

Wow! This is THE tool a chemist needs and you've got it. Do you mind sharing how much you paid for it? You had it repaired by the manufacturer?

Do you have a youtube channel? Would love to see that baby in action.

If you want a nice compound, try piperine. It's fairly big but still easy to isolate from pepper. Of course I've never done actual purity checks of my samples, but by MP they are supposed to be clean after a few recrystallizations

Bmoore55 - 24-4-2020 at 20:34

Thanks everyone. I have spent a few thousand dollars getting this all together so it’s not super cheep. But it doesn’t cost nearly as much as a new one. If anyone is interested I started a YouTube channel not too long ago. I will be adding more to it in the coming weeks. The link to my first video is here. https://youtu.be/rdOZQio-KtE

sodium_stearate - 25-4-2020 at 11:27

Could that possibly be used to analyze some samples
of a few unknown wax compounds?

The samples are various fragments of hard waxy
substances used many years ago for sound recording.

The ingredients of these are fairly well known, but there is
some missing data.

Got my own NMR update

Bmoore55 - 30-4-2020 at 12:22

Just wanted to show a new spectrum of Ibuprofen with some DCM and Acetone contamination. I am getting better at running this thing, but man am I rusty at my interpretation. Please leave your feedback, I would love to know what everyone thinks.

Ibuprofen.jpg - 81kB

Ubya - 30-4-2020 at 12:50

i just love it. i would help you more if i could, i'm studying an NMR course at UNI (at home lol) right now, but i've been distracted by so many things lol, my prof would have the jaw on the floor knowing an amateur has an nmr at home even if it isn't a 300MHz

DraconicAcid - 30-4-2020 at 12:52

Very nice! (Can I ask the make/model of it? The NMR dealer I'm trying to get my college to buy one from is curious as to what winds up on eBay.)

DraconicAcid - 30-4-2020 at 13:02

Quote: Originally posted by Ubya  
i just love it. i would help you more if i could, i'm studying an NMR course at UNI (at home lol) right now, but i've been distracted by so many things lol, my prof would have the jaw on the floor knowing an amateur has an nmr at home even if it isn't a 300MHz

I know- my jaw is still there.

Bmoore55 - 30-4-2020 at 13:32

The instrument is a Thermo Scientific Picospin 80. I think the resolution is pretty good considering it is the size of a microwave. However if I had my choice of a bench top NMR to have I would go with the Nanalysis unit since it also does 2D and carbon NMR. But hey beggars can’t be choosers.

G-Coupled - 30-4-2020 at 13:47

So cool - how much did that set you back?

Is it straightforward to use, and what if any consumables does it use?

Bmoore55 - 30-4-2020 at 14:44

I spent about $2K to get the instrument and a bit more to get it repaired. The consumables are really just dehydrated solvents, if you wanted to use them, and an additional “cartridge” whit is essentially a big computer chip with a flow cell. Other than that I typically use scintillation vials to prep samples which is another consumable. It’s also a good idea to have some kind of drying agent for your samples if you are concerned about water getting in your sample. I prefer anhydrous magnesium sulfate for a lot of my prep work if I need to dry stuff.

Bmoore55 - 30-4-2020 at 14:48

It’s not that difficult to run once you understand the quirks of the user interface. It’s not perfect but it’s a heck of a lot better than not having any NMR ;)

Texium - 30-4-2020 at 15:27

If you integrate one of the 1 proton peaks of the ibuprofen instead of the acetone as your “1.00”, assigning the ibuprofen peaks will be much easier, and you could roughly quantify the amount of the residual solvents in your sample. Looks great though!

Also I’m going to go ahead and merge this with your other thread. I don’t see why two are needed.

Bmoore55 - 30-4-2020 at 15:30

Thanks! It has been a good 10 years since I last worked up NMR data myself so I’m very rusty.

Bmoore55 - 30-4-2020 at 17:50

I went back and did the integration like you suggested and it worked like a charm. Molar ratio calculation is as follows:

Ibuprofen: 1
DCM: 0.1678
Acetone: 0.4572

If I back calculate from the molar mass then the Ibuprofen should make up 83.49%, the DCM is 5.77%, and the acetone is 10.75% by weight.

Texium - 30-4-2020 at 20:00

Cool, could you post an image of the updated spectrum?

Bmoore55 - 1-5-2020 at 06:37



Ibuprofen.jpg - 69kB