Sciencemadness Discussion Board

Phenyl Acetone transition to Amine by my path

milovess - 9-1-2020 at 21:28

My thought was
C6H5CH2(CO)CH3+Zn+2HCL>
ZnCL2+C6H5CH2(HCOH)CH3
............
C6H5CH2(HCOH)CH3+SOCL2>
C6H5CH2(HCCL)CH3+SO2+HCL
...........
C6H5CH2(HCCL)CH3+
AgNO2>AgCL+
C6H5CH2(HCNO2)CH3
.........
C6H5CH2(HCNO2)CH3+3Zn+6HCL>3ZnCL2+2H2O+
C6H5CH2(HCNH2)CH3

Sigmatropic - 9-1-2020 at 22:48

Congratulations on increasing the cost and decreasing the efficiency of the synthesis!
Go read up on reductive amination.

Sigmatropic

milovess - 9-1-2020 at 23:55

Seems you can't help other than chit chating. To create Hydrogen and plug there to reduce the Aryl derivate you waste energy, no matter whether Raney Nickel is used or not. I think my way is among the chiepst ones. Unless your Hydrogen doesn't come from electrolysis using inert metal electrodes and powered by photo diodes, the Hydrogen does no come for free.

milovess - 10-1-2020 at 04:08

Sigmatropic, I reread reductive amination here:
https:// erowid. org/ archive/ rhodium/ chemistry/reductive .amination. htm , so if I put all of the compounds in tin plated can covered by another one with force, and applying 90 celsius, should I expect the reaction to happen cuz I don't have autoclave. Another one is, can't I supply the hydrogen by nickel-metal hydride if it releases its Hydrogen at tolerable pressure by the tin coated cans, instead of adding Hydrogen thru the mixture by external source ?

[Edited on 10-1-2020 by milovess]

[Edited on 10-1-2020 by milovess]

j_sum1 - 10-1-2020 at 05:31

@ milovess. I don't see this thread going anywhere good.
Your posting history shows lack of understanding of some fundamentals, and here you are telling everyone how you would like to make amphetamine while at the same time using uppercase L for al[minium and chlorine.

This is not a site for drug cookery. It is within the site rules to discuss mechanisms but I doubt there will be much uptake if you cannot post something substantive or of significance.

If all you are interested in is fishing for recipes or posting inaccuracies then you are probably in the wrong place.

[/modding]