Quote: Originally posted by 497 | The industrial synthesis seems to consist of alkylation of phenol with propylene at high temperatures and pressures.. not very suitable for the
amateur.
According to this patent propofol can be effectively purified by low temperature recrystalization from petroleum ether. So even is the reaction you settle on
isn't very selective, it should be possible to purify it fairly easily.
Another possibility is the claisen rearrangement of 2-isopropylphenyl isopropyl ether. It works according to this patent. They used an alumina catalyst in an autoclave, but you might be able to figure out an easier way to do it.
[Edited on 19-7-2009 by 497] |
Perhaps phenol and PP feedstock in bomb? Phenol from aspirin, and polypropylene OTC. But I have a feeling the PP would have to be 1st
processed,amongst other things, because the harsh conditions required for favorable reaction might not work properly with the polymer (not certain,
any comments?). It's a shame MJ made this drug now infamous...it's chemical structure otherwise makes it very unpopular for controls (tjeeze, it's
just a substituted phenol). Intriguing like modafinil, but in reverse. The stimulant allows one to stay awake with a high quality of
wakefullness/alertness. But you have to pay the piper later on with additional sleep. Short time periods of propofol induced anesthesia, apparently,
could substitute for 8 hours of the real thing. Quite useful for touring, and those on tight schedules. |