kazaa81
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Amino acids synthesis...
Hi,
I am searching for a way to synthetize amino acids...anyone can help?
Obviously short-chain amino acids would be easier to synth. than long-chain ones.
Glycine would be the easiest.
Another idea I have in mind is to synth. them by breaking the peptidic chains of keratin, hair-polymer.
In attachment there is a text file I compiled.
[Edited on 6-5-2006 by kazaa81]
Attachment: Aminoacids-by-kazaa81.txt (4kB)
This file has been downloaded 1009 times
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nitroglycol
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Just an off-the-cuff suggestion for glycine- start with diethyl malonate, add NaNH2, isolate the product, then saponify the ester and decarboxylate?
I'm not sure how easily the decarboxylation would go, though, or if there are side reactions that would mess it up. I suppose if I had time I could
look it up, but at least you know where to start.
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leu
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A general method of synthesizing amino acids is by means of the Strecker reaction; from an aldehyde, a cyanide and ammonia. From:
http://chemistry2.csudh.edu/rpendarvis/aminoacids.html
The reaction begins with imine formation from an aldehyde and ammonia. The acid catalysis required for this comes from
ammonium chloride, a weak acid. An addition of hydrogen cyanide to the imine follows. This is analogous to the additions of nucleophiles to an
aldehyde or ketone which we studied earlier. In this instance, the cyanide ion serves as the nucleophile.
Also, see:
http://www.cem.msu.edu/~reusch/VirtTxtJml/proteins.htm
http://www.organic-chemistry.org/namedreactions/strecker-syn...
Chemistry is our Covalent Bond
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kazaa81
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Thank you nitroglycol and leu (leucine?)
The synthesis you posted is interesting, I've never hear about it...but one thing dislikes me...HCN, hydrogen cyanide...too much poisoning for
me..also for much of we here.
I've heard about this...
Glycine - from chloroacetic acid and ammonia (amino acetic acid)
my goal is to synthetize amino acids of purity not really great (90% or even less), but with impurities not poisoning as cyanides....my impurities
would be somewhat like CaCO3...very safe!
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guy
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| Quote: |
Glycine - from chloroacetic acid and ammonia (amino acetic acid) |
You probably will get a mixture of glycine, ammonium chloride, and 2-chloroethan-1-amide.
[Edited on 5/7/2006 by guy]
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kazaa81
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This thread seems interesting to me...
http://www.sciencemadness.org/talk/viewthread.php?tid=2210#p...
If one escape the last steps, one has a solution of amino acids, from hairs.
However, how make the HCl safe? Like using the solution as food-integrator?
Neutralizing with sodium bicarbonate (NaHCO3)?
any help appreciated
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Niels Bohr
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What are you going to use it for. I'm just curious.
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kazaa81
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to bohr:
| Quote: | Originally posted by kazaa81
......using the solution as food-integrator?.....
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Using a solution as food integretor what would mean?
If that's still not clear enough, I would mean using a solution (or powder) of amino acids of the above experiment as an aid in diets poor of some of
them. All this from cheap hairs!
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kazaa81
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Any help welcomed
[Edited on 14-5-2006 by kazaa81]
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