Difference between revisions of "Salicylic acid"
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[[File:Sali22.jpg|thumb|366px|Fine, needle-like crystals of salicylic acid produced through recrystallization.]] | [[File:Sali22.jpg|thumb|366px|Fine, needle-like crystals of salicylic acid produced through recrystallization.]] | ||
| − | '''Salicylic acid''' is the organic compound with the chemical formula C<sub>6</sub>H<sub>4</sub>(OH)COOH. It is an example of a phenolic acid. It is the active metabolite of [[aspirin]] and is also used in many other medications such as skin-care products. | + | '''Salicylic acid''' is the organic compound with the chemical formula C<sub>6</sub>H<sub>4</sub>(OH)COOH. It is an example of a phenolic acid. It is the active metabolite of [[acetylsalicylic acid|aspirin]] and is also used in many other medications such as skin-care products. |
== Properties == | == Properties == | ||
| − | |||
=== Chemical === | === Chemical === | ||
Salicylic acid can be converted to phenol via heating. | Salicylic acid can be converted to phenol via heating. | ||
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==Preparation== | ==Preparation== | ||
{{Main|Synthesis of salicylic acid}} | {{Main|Synthesis of salicylic acid}} | ||
| − | Salicylic acid can be easily synthesized using either [[methyl salicylate]] or [[ | + | Salicylic acid can be easily synthesized using either [[methyl salicylate]] or [[acetylsalicylic acid]] (aspirin) as the primary precursor, but because methyl salicylate may not be as cheaply or easily obtained as aspirin, it is usually synthesized from the latter, which is also typically seen as the easier process. |
Production from aspirin requires the acetylsalicylic acid to be refluxed in the presence of a stronger acid(often [[hydrochloric acid]]) for a period of time, hydrolyzing it to salicylic acid and [[acetic acid]]. The product can then be washed and recrystallized. | Production from aspirin requires the acetylsalicylic acid to be refluxed in the presence of a stronger acid(often [[hydrochloric acid]]) for a period of time, hydrolyzing it to salicylic acid and [[acetic acid]]. The product can then be washed and recrystallized. | ||
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== Projects == | == Projects == | ||
| + | * Make aspirin | ||
* [[Esterification]] of [[salicylic acid]] with [[methanol]] to make [[methyl salicylate]] | * [[Esterification]] of [[salicylic acid]] with [[methanol]] to make [[methyl salicylate]] | ||
* Reaction of salicylic acid with carbamide and boric acid to form Salicylamide | * Reaction of salicylic acid with carbamide and boric acid to form Salicylamide | ||
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===Storage=== | ===Storage=== | ||
| + | No special storage is require, salicylic acid can be stored in any clean container. | ||
===Disposal=== | ===Disposal=== | ||
| + | Salicylic acid can be safely poured down the drain, as it does not pose any danger for the environment. | ||
== Gallery == | == Gallery == | ||
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<references/> | <references/> | ||
===Relevant Sciencemandess threads=== | ===Relevant Sciencemandess threads=== | ||
| + | *[http://www.sciencemadness.org/talk/viewthread.php?tid=10914 Salicylic acid] | ||
| + | *[http://sciencemadness.org/talk/viewthread.php?tid=11753 preparation of salicylic acid from anthranilic acid] | ||
[[Category:Chemical compounds]] | [[Category:Chemical compounds]] | ||
Revision as of 19:00, 29 October 2015
Salicylic acid is the organic compound with the chemical formula C6H4(OH)COOH. It is an example of a phenolic acid. It is the active metabolite of aspirin and is also used in many other medications such as skin-care products.
Contents
Properties
Chemical
Salicylic acid can be converted to phenol via heating.
Physical
Salicylic acid is most often encountered as a fine, fluffy crystalline powder or as needle-like crystals which are difficult to compact. It has a somewhat minty and irritating odor. Salicylic acid is quite soluble in alcohols, acetone, ether, and nonpolar solvents such as benzene and toluene, has low solubility in cold to warm water, and high solubility in boiling water.
Preparation
Salicylic acid can be easily synthesized using either methyl salicylate or acetylsalicylic acid (aspirin) as the primary precursor, but because methyl salicylate may not be as cheaply or easily obtained as aspirin, it is usually synthesized from the latter, which is also typically seen as the easier process.
Production from aspirin requires the acetylsalicylic acid to be refluxed in the presence of a stronger acid(often hydrochloric acid) for a period of time, hydrolyzing it to salicylic acid and acetic acid. The product can then be washed and recrystallized.
Salicylic acid can also be prepared from store-bought oil of wintergreen (methyl salicylate); a detailed write-up for this process can be found here.
Availability
Salicylic acid, while usually produced using aspirin as a precursor with ease, can also be purchased in solution as various skin-care products for treating warts or acne, those these can be both expensive and impure, as well as highly diluted.
It can also be found in food stores as preservative, usually as a ester.
Projects
- Make aspirin
- Esterification of salicylic acid with methanol to make methyl salicylate
- Reaction of salicylic acid with carbamide and boric acid to form Salicylamide
- Make phenol
Handling
Safety
Salicylic acid has the ability to break down lipids in the skin, causing symptoms ranging from dryness and irritation at low concentrations to mild acid burns at higher ones. When ingested orally in large amounts it can cause salicylate intoxication, which may produce very serious side effects.
Storage
No special storage is require, salicylic acid can be stored in any clean container.
Disposal
Salicylic acid can be safely poured down the drain, as it does not pose any danger for the environment.
