Difference between revisions of "Quinine"
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(Created page with "{{distinguish|quinone}} {{Chembox | Name = Quinine | Reference = | IUPACName = (R)-(6-Methoxyquinolin-4-yl)[(1S,2S,4S,5R)-5-vinylquinuclidin-2-yl]methanol | PIN = | Systematic...") |
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| Line 66: | Line 66: | ||
| pKb = | | pKb = | ||
| Solubility = 0.05 g/100 ml (15 °C) | | Solubility = 0.05 g/100 ml (15 °C) | ||
| − | | SolubleOther = | + | | SolubleOther = Soluble in [[carbon disulfide]], [[chloroform]], [[ethanol]]<br>Slightly soluble in [[glycerol]]<br>Insoluble in [[ammonia]], [[petroleum ether]] |
| − | | | + | | Solubility1 = 1.25 g/100 ml |
| + | | Solvent1 = benzene | ||
| + | | Solubility2 = 83.3 g/100 ml | ||
| + | | Solvent2 = chloroform | ||
| + | | Solubility3 = 0.4 g/100 ml | ||
| + | | Solvent3 = diethyl ether | ||
| + | | Solubility4 = 125 g/100 ml | ||
| + | | Solvent4 = ethanol | ||
| + | | Solubility5 = 5 g/100 ml | ||
| + | | Solvent5 = glycerol | ||
| Taste = Extremely bitter | | Taste = Extremely bitter | ||
| VaporPressure = 1.54·10<sup>-10</sup> mmHg at 25 °C | | VaporPressure = 1.54·10<sup>-10</sup> mmHg at 25 °C | ||
| Line 110: | Line 119: | ||
}} | }} | ||
}} | }} | ||
| − | '''Quinine''' is | + | '''Quinine''' is an alkaloid isolated from Cinchona bark, used as medication to treat malaria and babesiosis. |
==Properties== | ==Properties== | ||
| Line 127: | Line 136: | ||
==Preparation== | ==Preparation== | ||
| − | Quinine is best extracted from | + | Quinine is best extracted from Cinchona tree bark than synthesized from precursors. |
==Projects== | ==Projects== | ||
Revision as of 19:34, 18 November 2018
Not to be confused with quinone.
| Names | |
|---|---|
| IUPAC name
(R)-(6-Methoxyquinolin-4-yl)[(1S,2S,4S,5R)-5-vinylquinuclidin-2-yl]methanol
| |
| Other names
Chinine
Qualaquin Quinate Quinbisul | |
| Properties | |
| C20H24N2O2 | |
| Molar mass | 324.42 g/mol |
| Appearance | White solid |
| Odor | Odorless |
| Melting point | 177 °C (351 °F; 450 K) |
| Boiling point | Decomposes |
| 0.05 g/100 ml (15 °C) | |
| Solubility | Soluble in carbon disulfide, chloroform, ethanol Slightly soluble in glycerol Insoluble in ammonia, petroleum ether |
| Solubility in benzene | 1.25 g/100 ml |
| Solubility in chloroform | 83.3 g/100 ml |
| Solubility in diethyl ether | 0.4 g/100 ml |
| Solubility in ethanol | 125 g/100 ml |
| Solubility in glycerol | 5 g/100 ml |
| Vapor pressure | 1.54·10-10 mmHg at 25 °C |
| Hazards | |
| Safety data sheet | Sigma-Aldrich |
| Lethal dose or concentration (LD, LC): | |
| LD50 (Median dose)
|
1,800 mg/kg (guinea pig, oral) |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Quinine is an alkaloid isolated from Cinchona bark, used as medication to treat malaria and babesiosis.
Contents
Properties
Chemical
Quinine reacts with acids forming water soluble salts.
Quinine will slowly oxidize upon exposure to air over long periods of time, in both free and salt form, turning dark.
Physical
Quinine is a colorless or white solid, with a potent bitter taste.
Availability
Quinine is sold online.
Tonic water has small amounts of quinine, though not enough for it to be an economical source.
Preparation
Quinine is best extracted from Cinchona tree bark than synthesized from precursors.
Projects
- Compound collecting
- Tonic water
- Make fluorescent drinks
- Anti-malaria drug
- Demonstration of triboluminescence
Handling
Safety
Exposure to quinine is known to cause abnormal heart rhythms.
Storage
Quinine should be kept in plastic or glass bottles, in dark places.
Disposal
Can be safely poured down the drain or in trash.
