enkay
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Bromination
Hi !
I'm trying Bromination of 4-Phenyl Butyric acid to get 2(alpha)-Bromo-4-Phenylbutyric acid.
Is this synthesis possible using Bromine liq. & 4-Phenylbutyric acid with any procedure ?
Awaiting your replies !
Thanks in advance,
Enkay
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enkay
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Again, one more question to my above posting......
Is this bromination possible using any bromine containing reagents instead of hazardous bromine liq. ?
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=SkyNET=
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I think NH4Br+H2O2 would do it.
Bromine isn't really too hazardous. It's easy to handle and you can't really get hurt if you kow what your doing.
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Nicodem
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Your question can only be answered by searching Beilstein or SciFinder. The only other way is to experimentally find the conditions for a Hell-Volhard-Zelinsky reaction that would leave the phenyl ring un-brominated. Since the usual reaction conditions are not so harsh I would say it
is possible. Anyway, for details you should search literature references instead of asking in a forum.
Edit: SkyNet, he is not asking about brominating the aromatic ring. Anyway, even if he would, not even Br2 would be good enough without a Lewis acid
so you can be sure NH4Br + H2O2 would not do it.
[Edited on 9-6-2006 by Nicodem]
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=SkyNET=
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D'oh
Thanks
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