Cou
National Hazard
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Registered: 16-5-2013
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Has anyone ever done a Suzuki coupling at home? Is it doable?
Just curious to know if advanced organic reactions like this have been done by amateurs.
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clearly_not_atara
International Hazard
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Registered: 3-11-2013
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A: yes, you can
and
B: why would you?
The Suzuki coupling is not technically difficult. The preparation of arylboronic acids is difficult. However, the preparation of arylboronic acids is
not difficult if you have access to tetrahydroxydiboron or its derivatives.
However, the preparation of tetrahydroxydiboron and its derivatives, or its precursor tetrachlorodiboron, is damn near impossible to
perform at home. But if you want to perform Suzuki couplings you can probably just order some. It's not particularly suspicious.
EDIT: There is also a Grignard preparation of boronic acids from boric esters, but if you have already prepared an aryl Grignard reagent, you probably
have no use for the Suzuki coupling! The reaction of your aryl Grignard with an aldehyde is usually equivalent to the Suzuki coupling of the boronic
acid with a vinyl halide.
[Edited on 23-4-2020 by clearly_not_atara]
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