gorecore
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Glutaric Anhydride Purification
hi, im looking an easy way to purifiy the Glut. Anhydride. because i always have the mixture of the acid and the anhydride. and i need it for a quick
reaction..
thanks
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Paddywhacker
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That sounds interesting. Could you post a link to the prep, please.
Your problem looks like pretty standard workup. I would suggest disolving everything in dichloromethane and extracting the free acid into aqueous
sodium bicarbonate. Then dry and evaporate the DCM.
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not_important
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Um .. reflux with excess acetic anhydride, then fractionate - AcOH @ 118 C, (AcO)2O @ 140 C, glutaric anhydride @ 288 C. Recrystallise from
solution in hot ether, if there's only a small percent of the acid in the anhydride to start with, just do the recrystallisation.
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