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Sandmeyer
National Hazard
Posts: 784
Registered: 9-1-2005
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Mood: abbastanza bene
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Quote: Originally posted by Nicodem  |
In short, I think the Bayer-Villiger on veratraldehyde, O-methylation and Vilsmeier-Haack formylation as proposed by Sandmeyer is a more convenient
and reliable route.
[Edited on 23/6/2010 by Nicodem] |
Nope, sorry, I never proposed Vilsmeier-Haack, since it is not OTC, I proposed OTC methylation, OTC Baeyer-Villager on veratraldehyde and OTC Duff
formylation.
[Edited on 23-6-2010 by Sandmeyer]
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Nicodem
Super Moderator
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Registered: 28-12-2004
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| Quote: Originally posted by Sandmeyer | | Nope, sorry, I never proposed Vilsmeier-Haack, since it is not OTC, I proposed OTC methylation, OTC Baeyer-Villager on veratraldehyde and OTC Duff
formylation. |
Pardon. I had the route in mind rather than the specific reactions and methods. The thing is that Vilsmeier-Haack on 1,2,4-trimethoxybenzene is
supported by several literature examples, while I was unable to find examples for the modified Duff. It might work with hexamine/AcOH though, but
whether someone prefers OTC or OTS ("of the shelf") depends, not only on what is available in the local shops and on lab shelves, but also which
method is already verified. Which is not to say that one should always chose the verified method. For example, I prefer to live on the edge and have a
stressful life, so I often chose to check new methods. 
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