morganism
Hazard to Others
Posts: 105
Registered: 8-12-2012
Location: Az.
Member Is Offline
Mood: No Mood
|
|
Bio catalyst for handed isomers found
Using bio catalysts to make handed isomers with amino acids, alcohols and amines. Low temp too...
http://www.sciencedaily.com/releases/2013/02/130213132317.ht...
|
|
kavu
Hazard to Others
Posts: 207
Registered: 11-9-2011
Location: Scandinavia
Member Is Offline
Mood: To understand is to synthesize
|
|
It's a neat workaround, but it's not anything substantially novel. Organocatalysis is nowadays a vibrant field and much research is going on in many
universities.
[Edited on 13-2-2013 by kavu]
|
|
zed
International Hazard
Posts: 2281
Registered: 6-9-2008
Location: Great State of Jefferson, City of Portland
Member Is Offline
Mood: Semi-repentant Sith Lord
|
|
Worst writing ever. The article endeavors to relay some information....apparently.
|
|
smaerd
International Hazard
Posts: 1262
Registered: 23-1-2010
Member Is Offline
Mood: hmm...
|
|
Tried finding an article because yea that article was completely unintelligable...People have long used enantiomers of amino acids for chiral
resolutions and enantioselective reactions in one way or another. They really should have just posted the abstract of the article and a citation
hahaha.
http://www.nature.com/nature/journal/v494/n7436/full/nature1...
|
|
Dr.Bob
International Hazard
Posts: 2718
Registered: 26-1-2011
Location: USA - NC
Member Is Offline
Mood: No Mood
|
|
It is a nice paper, but limited to mostly allyl boron additions, and some related compounds. While the chemistry is very useful for those, that is a
fairly limited reagent, being added to a glycine phophoryl-imine, which is not a very common starting material either. But I am sure that Aldrich or
someone will start selling it soon. It would be nice to see a more general chiral catalytic addition reaction, but most catalyst are pretty
specific, and only a few chiral catalysts are useful for many substrates. This chemistry is complementary to the most common way to make chiral
amino acids by cat. hydrogenation, which is used to make phenylglycine and related AAs in ton amounts. But it would not work well for allyl
compounds, as they would likely be reduced as well.
|
|