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vulture
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Fluoroacetic acid...gifblaar...South Africa...
One shouldn't accept or resort to the mutilation of science to appease the mentally impaired.
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Hermes_Trismegistus
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| Quote: | Originally posted by Blind AngelBTW: you told me: Sigh...the frog evil
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Yes.......isn't he? after all, he is posting in the "Fastest acting poisons catagory"!
Arguing on the internet is like running in the special olympics; even if you win: you\'re still retarded.
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FritzHaber
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nicotine freebase acts pretty quickly in appropriate dose
hydrogen cyanide too
but my personal favourite is anatoxin-a1
check it out
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Ramiel
Vicious like a ferret
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Vulture, we in Western Australia use Sodium Fluroacetate in baits to kill non-native pests like foxes and cats (the native species are resistant to
it).
see here for an excellent paper on <html><a href="http://www.ecwa.asn.au/info/teneighty.html">so called
1080.</a></html>
Caveat Orator
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Prince_Lucifer
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Tetrodoxin!
Tetradoxin is an extremely potent sodium channel blocker which if ingested, will cause muscle paralysis then death due to respiratory failure!
Tetradoxin is found in the skin, muscles, liver and ovaries of the japanese fugu fish.
(A form of puffer fish) Scientists claim that the total amount of tetrodoxin in one fugu fish, is enough to kill 30 adults. They also claim that is
1,250 times deadlier than HCN!
Lethal dose for an adult is 1-2mg
When tetradoxin is diluted to a non-lethal level, scientists also claim that it is 160,000 times more potent than cocaine HCl.
Believe it or not, there is a commercial form of diluted tetradoxin for sale as a very effective painkiller. However it is diluted extremely heavily,
no doubt 
Here are some other tidbits that are related to past discussion:
During a lethal injection, a fatal dose of potassium chloride is administered intravenously. The large influx of potassium ions interrupts the wave of
depolarization to the heart muscle resulting in cardiac arrest. A nondepolarizing paralyzing agent, such as pancuronium bromide or tubocurarine
chloride, plus a lethal dosage of a general anesthetic, such as sodium thiopental (sodium pentothal) are usually given before the potassium chloride
is administered.
This is also relavent so i will tell what i know. I had to research this when i was younger.
D-Tubocurarine can also be used successfully as the nondepolarizing paralyzing agent used in conjunction with the above process.Tubocurarine is the
active ingredient of curare, an extract from the bark and stems of the South American vine (Chondodendron tomentosum). Amazonian Indians use the gummy
extract to coat the poison darts of their blowguns. The isoquinoline alkaloid D-tubocurarine blocks acetylcholine receptor sites at neuromuscular
junctions, causing relaxation and paralysis of muscles, including respiratory organs and the heart.
The sea snails mentioned previously inject a poison called conotoxin. This is a calcium channel blocker, which prevents the flow of calcium ions to
the heart. This in turn affects the hearts ability to contract, which causes all sorts of problems, but will only kill if help is not sought. Poisons
are cool
[Edited on 15-5-2004 by Prince_Lucifer]
[Edited on 15-5-2004 by Prince_Lucifer]
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chemoleo
Biochemicus Energeticus
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The most toxic substance known...
Is botulinum toxin!
It's produced by a rather common bacterium, and is sometimes found in contaminated canned food... nice!
According to some source, a single gram would kill (if dispersed nicely, then inhaled) kill 1 million people. You can guess that bioweapons defense
are getting major worries about it.... Saddam made Kg's of it, didnt you know? 
Anyway, it acts on (what else) the acetylcholine receptors. Specifically, it's a zinc protease, that cleaves certain fusion proteins
(synaptotagmins/brevins?) that trigger the release of acetylcholin into the neuromuscular junction (the interface between neuron and muscle cell).
You can imagine that it takes over control of all your muscles.
Interestingly enough, you may have heard of botox therapy - whereby the toxin is injected into certain face muscles so that they cant be used... and
wrinkles disappear. Ever wondered why Cher seems to have a mask-like face? That's why!
Never Stop to Begin, and Never Begin to Stop...
Tolerance is good. But not with the intolerant! (Wilhelm Busch)
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Prince_Lucifer
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Saddam and his toys!
In 1991 after the gulf war, Sadaam Hussein told the UN inspectors that his scientists had created 19,000L of concentrated botulinum toxin!
Theoretically, this is enough to kill everyone on earth 3 times
Did you also know that it is common practice for americans to host botox parties?!
As crazy as this sounds, surgeons have devised a clever way to make sure all the botox is used before it is rendered useless.Apparently after 30min of
atmosphere exposure, the botox deteriorates to a point where it is useless!
Hey guys, I am going to host a botox party with bowls of vicoden for snacks, who wants to come?
[Edited on 16-5-2004 by Prince_Lucifer]
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Norm Alara
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Fastest, not most potent
A nice slug of heroin (acetyl morphine)
will kill you as fast as your heart
can pump it to depress your respiratory
center. It is the preferred way
to go (seriously -I've got a terminally
ill friend who'se asked MDs.).
Monoxide being
gentle too, but not fast. Barbituates
(supposedly not hard to synthesize,
see _The Curve of Binding Energy_)
were synergisticly gentle with ethanol
(as Ms. Monroe, etc found out).
Stopping the ion channels (eg TTX
or KCl i.v.) would be fast too.
Note that in the death penalty
the first injection is just to
anesthetize the dude.
And a capsule or solution of cyanides
was certainly used by spies about
to be captured. GAME OVER is better
than torture.
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battery
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you want a fastacting poison
well not a proper poison but if u get pure alcohol (ethanol methaol pentanol butanol ect) or as pure as possible find the biggest syringe fill
completely with the alcohol and directly inject into blood stream (best places are the temples, neck, eyes and chest) that will kill them in about 1-2
minutes depanding on how pure the alcohol is and how much you inject the more you inject the faster it acts!!!
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YT2095
International Hazard
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Carfentanyl would be my choice, it`s not Technicaly a poison in extremely low doses, but just a fraction over and you simply never wake up.
thinks like clostridium botulin toxin isn`t particularly fast either, it works by effecting the 9th 10th and 12th cranial nerves govorning swallowing,
the coordination of swallowing and respiration.
[Edited on 29-6-2006 by YT2095]
\"In a world full of wonders mankind has managed to invent boredom\" - Death
Twinkies don\'t have a shelf life. They have a half-life! -Caine (a friend of mine)
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JohnWW
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| Quote: | Originally posted by Ramiel
Vulture, we in Western Australia use Sodium Fluoroacetate in baits to kill non-native pests like foxes and cats (the native species are resistant to
it). see here for an excellent paper on <html><a href="http://www.ecwa.asn.au/info/teneighty.html">so called 1080.</a></html>
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Contrary to what you say, CH2FCOONa DOES kill Australian marsupials. The same stuff is used here in New Zealand to kill introduced pest mammals, as an
alternative to warfarin (bromocoumarin) derivatives, mostly rats (rattus rattus, rattus norvegicus, and the smaller and less harmful Polynesian rat,
rattus exulans, and the well-known two-legged rat), mice, wildcats, stoats/ermines, weasels; and especially the Australian brushtail opossum, which
latter is N.Z.'s number one pest. They are so bad that I have half a mind to kill some Australian brushtail opossums, and send them through the post
to Howard (the Australian "Prime Minister") in Canberra A.C.T.
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oxydiser
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This wiki article shows how 1080 resistance is possesed by mainly west coast natives due to high natural fluorine content in the soil. East coast
brushtails have never developed resistance.
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Ozone
International Hazard
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Hello,
Why has no one mentioned the very well optimized acetycholinesterase inhibitors that are well known, viz. GB (Sarin) and VX. These compounds are not
only active in very small amounts (VX, LD50, subcutaneous, rabbit, 15.4 ug/kg(Merck, 11the Ed.)). These agents are not only chosen for potency, but
for speed of action as well. AchE's are very rapid, with this agent, leading to S.L.U.D.D. (salivation, lachrymation, urination, defecation, and
death) within minutes of exposure. Please, Please, Please- NO ONE attempt to EVER go near something like this. It's a horrible (but swift) way to go.
By the way, atropine is the only recourse for this toxidrome. Of course atropine overdose (avoid the datura people) is physostigmine (a very potent
ACHE inhibitor). Pralidoxime is not very useful with organophosphate intoxiation.
Botulinus toxin can take hours, even days, to exert is inevitably lethal effect. Tetrodotoxin as well, does take a while. Ill fated fugu fans usually
die at home or in the hospital, not at the restaurant.
Curare? Phosphine? IV KCl is instantaneous, interrupting the balance of the Na+/K+ pump cycle in cardiac muscle--instant cardiac arrest, but the doses
are large, and a bolus need be administered IV.
CN and N3 are about the same, fairly rapid; interruption of electron transport is not a nice way to go.
Dinitrophenols are nasty. I discovered once that they will penetrate nitrile gloves effortlessly leading to yellow fingers, raging migrain, profuse
sweating, rapid heartbeat, and extreme fear. Lucky for me, it was sublethal, but decoupling electron transport sucks. It turns out that the symptoms I
had reflected a dose that was very close to lethal. In this case, these are toxic not only at low dose, but quickly, and they are transdermal. (DO NOT
HANDLE THESE COMPOUNDS WITH NITRILE GLOVES).
Not so quick, but insidious, dialkyl mercury compounds (see Dartmouth, this is both so sad and so scary).
While we are at it, how about elemental F? Quite scary. Cl is also infamous (as is phosgene), but there is usually a lag period.
How about poisons that are far more insidious, the ones that don't let you know when you have been "bitten"? These really scare the hell out of me.
Stay safe everyone,
O3
-Anyone who never made a mistake never tried anything new.
--Albert Einstein
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phangue
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My favorite is aconitine derived from the plant, munkshood
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MadHatter
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Lead
Lead poisoning - by way of bullet !
From opening of NCIS New Orleans - It goes a BOOM ! BOOM ! BOOM ! MUHAHAHAHAHAHAHA !
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Nerro
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dinitrophenol screws up the proton pump, I believe bodybuilders use something similar to it to increase their core temperature quickly.
I presume a reasonable dose of that stuff combined with a good dose of KCN could kill someone pretty quickly.
#261501 +(11351)- [X]
the \"bishop\" came to our church today
he was a fucken impostor
never once moved diagonally
courtesy of bash
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Elawr
Hazard to Others
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Carbon dioxide is super fast in high concentrations, Just one lungful can cause loss of consciousness and collapse in seconds followed by rapid
vascular collapse and death from asphyxia. You may have heard of the village in Africa , Nigeria maybe, where a deep volcanic lake supersaturated with
dissolved CO2 was disturbed by a seismic tremor. Like a giant bottle of soda pop, the lake literally exploded and sent a veritable tsunami of CO2 gas
rushing down a river valley. An entire village of hundreds was snuffed out in minutes along with whole populations of wildlife. Most were killed as
they slept, their corpses found still in bed. Apparently death came so quickly and with so little warning, that most never even knew what hit them!
[Edited on 8-11-2006 by Elawr]
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12AX7
Post Harlot
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Lake Nyos, if I'm not mistaken.
Tim
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Elawr
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Yeah.. that was it - Lake Nyos. After the disaster, they sunk a big vertical standpipe from the lake surface down into the depths so that excess CO2
could siphon off gradually. Hopefully this will prevent future catastrophic CO2 blowups.
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not_important
International Hazard
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On the other hand, experiments with mixtures of O2 and CO2 often give results similar to ketamine - out of body, going-to-the-light, and so on. CO2
is used in inhalation therapy, both conventional and non-conventiona. However, it's not a DIY sort of trick...
http://www.aetna.com/cpb/data/CPBA0428.html
http://ajp.psychiatryonline.org/cgi/content/abstract/110/10/...
[Edited on 8-11-2006 by not_important]
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Ozone
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Egads man!
This is probably a synergistic combination. Dinitrophenol was also used in the 1930's as a weight loss drug...problem was, people would go off of the
drug and continue losing weight . The thought of a dinitrophenol:KCN cocktail
is absolutely frightening--this would serve to both decouple oxidative phosphorylation while lowering ATP synthesis (increasing O2 requirements) *and*
the means of cycling O2 (by binding cytochrome metalloenzyme a3--and many others, including cyp-450) to ultimately fuel it. Yikes! A train wreck, only
faster.
Please see, Griffith (2002), pp. 622.
http://taylorandfrancis.metapress.com/media/570cd1rxqr5juknw...
and,
http://www.emedicine.com/emerg/topic118.htm
This is probably very nasty.
Avoid. Please, no one get into this.
Live long and prosper,
O3
-Anyone who never made a mistake never tried anything new.
--Albert Einstein
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Ozone
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Oh, and while we are talking about nasty, rapid mass casualties, such that seen in Camaroon (CO2), how about Bhopal, India (Mfg. Carbaryl, Union
Carbide, Dec. 3, 1984)? This was a mass release of methyl isocyanate, probably resulting from a disgruntled employee. At least 3,800 were killed and
200,000 (estd.) exposed.
This must have been a *terrible* way to go.
See: Indian J. Exp. Biol. 26, pp. 149-176, 201-204 (1988).
and,
bhopal.com
A moment of silence for Bhopal...
O3
-Anyone who never made a mistake never tried anything new.
--Albert Einstein
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Elawr
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| Quote: |
This must have been a *terrible* way to go.
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Indeed.... Smother me with CO2 any day.
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unionised
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Bhopal was truly a nasty example of mankind's foolishness and (possibly) malice (though it might not have happened if it weren't for a drought).
However,since people are still dying from the delayed effects of the MIC released at Bhopal, it can hardly be listed as one of the fastest acting
poisons. I imagine many of its victims wished it was faster.
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Ozone
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Too true, Unionized.
It was rather like a nuke, very fast in the primary zone, and horrendously slow beyond that. But, would this not be more a factor of a point-source
where dilution occurs relative to the origin rather than of the lethal threshold of the material itself (say, in a single subject)? Those who lived
were sublethally exposed. The scary thing is that the sublethal cases are chronic (and terrible), and in some cases, progressive.
Bhopal was a tragedy on many fronts. It was so horrible that it underscored the beginning of the "Science is evil" campaign--the same movement that
led to the notion that all chemicals are to be feared (ask a few people what a "chemical" is, these days).
There is a lesson here, let's try not to forget it. There is a tendency in society today to forget about the past and repeat it (which,
more-and-more, is being promulgated by "political correctness" that says we cannot remind people of past transgressions because we might *offend*
their delicate sensibilities).
Best to you all, take care,
O3
-Anyone who never made a mistake never tried anything new.
--Albert Einstein
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