Ozonelabs
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Ozonelabs- Synthesis of Lidocaine
The long promised Lidocaine synthesis!
Any questions or comments greatfully received.
Regards,
The Ozonelabs Team
Attachment: Lidocaine.pdf (363kB) This file has been downloaded 2993 times
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Picric-A
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Awesome write-up as ever Ozonelabs!
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DJF90
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The synthesis isn't up to your usual standard, and you do not cite a reference for the procedure you used (unless you came up with it yourself?).
Additionally, you haven't performed any analysis to confirm that it is actually Lidocaine you've made, not even a melting point. You should also
recrystallise your material before such analysis, and although I'm fairly certain what you have made is the desired product, you shouldn't just assume
this without analytical evidence. I've attached a paper that does the reaction on a smaller scale and gets a higher yeild of crude product; you might
want to try their procedure and compare it to your own.
I hope you'll take my criticism constructively and not find it disheartening.
Attachment: Lidocaine prep.pdf (16kB) This file has been downloaded 1939 times
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Ozonelabs
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Analyses:
Proton NMR on intermediate a-chloro-2,6-dimethylacetanilide:
Proton NMR on final Lidocaine:
Carbon NMR on final Lidocaine:
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UnintentionalChaos
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What am I looking at? Solvent? Are they referenced? Surely you shouldn't have a peak at 0 for referenced HNMR unless it's tetramethylsilane.
Department of Redundancy Department - Now with paperwork!
'In organic synthesis, we call decomposition products "crap", however this is not a IUPAC approved nomenclature.' -Nicodem
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