joe69cool
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atropine
I had a brief talk several months ago with a Marine (CBR specialist) who was telling me that while the soviet's in their day had several nerve agent
treatments the USA only had atropine. I don't speak russian (yet) so I am wondering if any russian bees had any comments on this. I have several
ideas as to what the soviets may have developed based on the atropine structure, though it may be irrevilent since the days of nerve gas are by and
large gone. Just Curious.
\"Why oh why didn\'t I take the blue pill?\"
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Sandmeyer
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Germans had these agents first. During WWII tabun and sarin were stockpiled by Germany while US/UK had no knowledge let alone the antidote against
organophosphorus cholinesterase inhibitors, lucky for them Germans didn't put them in use. As far as Russia goes, they captured a production plant in
East Germany and moved all those resources to Russia (including workers/chemists) to continue the production. Wonder if there were similar facilities
for speed production, since it was produced in copious amounts during the WWII.
[Edited on 7-9-2006 by Sandmeyer]
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Biginelli
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Relatively easy to answer. Atropine was widely used during 1950s-1960s, however, this led to numerous drug abuse accidents, so in 1970s-80s atropine
was replased by budaxime and aphine (or affine, exact ingredients are not known - kinda top secret; however, it includes phenamine and atropine...).
Rarely tarene (a drug containing a bit of aprofene) was used.
Such an antidote is included as two small syringes in an individual medikit, which is a standard equipment piece of chemical defence forces.
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Chris The Great
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They also add some other stuff to help remove the organophosphate agent from the receptors and reactivate the enzymes, and sometimes diazepam to
prevent seixures. I was under the impression atropine was still used in most injectors.
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JohnWW
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Atropine, an alkaloid found in belladonna with has a 7-carbon aliphatic ring bridged by a tertiary-amine N atom, is used as a muscle relaxant in small
doses, e.g. as an anti- diarrhetic.
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Glucose Oxidase
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They used oximes to free acetylcholinesterase and get it back to work..
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franklyn
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www.sciencemadness.org/talk/viewthread.php?tid=623#pid85623
and the rest of that thread.
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