stimo-roll - 15-12-2007 at 05:53
Hi. Interesting reaction for preparation phenylacetonitriles - http://www.erowid.org/library/books_online/pihkal/pihkal147.... Substituted bromobenzene reacted wia strong base (LDA) give yne-derevate, which
reacts wia acetonitrile give subst-phenylacetonitrile. Anybody know this type reaction examples in literature? Can LDA be replaced with t-BuOK?
[Edited on 15-12-2007 by stimo-roll]
[Edited on 15-12-2007 by stimo-roll]
stoichiometric_steve - 15-12-2007 at 08:21
why bother, when it is clearly stated that it is not easy to purify the resulting mixture of products - and the yield is also shitty.
vulture - 15-12-2007 at 11:41
t-BuOK is not basic enough. And we don't like cookery threads here...