Yes, it’s the MAO enzymes which inhibit activity of a lot of phenylethylamines because they’re broken down so quickly - take enough to saturate
the enzymes and it will produce effects as long as it can cross the BBB. Of course, their duration is very short because the enzymes won’t be
‘locked up’ for long, but providing enough molecules have access to the receptors then you will get effects.
PEA certainly is active, I can personally attest to that because I have put over a kilogram of the stuff through my body over the past two years, with
predictable dosing, tolerance, and duration. The molecule I’m referring to is what you think, the benzene molecule with an aminoethyl group -
nothing else apart from that except for the HCl salt since the freebase is liquid and highly basic.
From my experience, dosing with no tolerance is as follows:
1-1.5g orally taken in 2-3 lots of 500mg encapsulated and ground salt.
Onset of action is approximately 20 minutes and requires a completely or near empty stomach otherwise no effects are experienced.
Duration lasts between 30 and 45 minutes with after effects lasting up to two hours, mood is altered for several hours.
Effects: potential stomach discomfort before manifestation of effects rapid increase in amphetamine like stimulation peaking within 10 minutes,
tingling extremities (not pins and needles but like you can feel the blood moving; vasoconstriction), pressure in sinuses, intense ability to
focus/greater ignorance of distractions but attention can still be consciously diverted easily. Even with a mild overdose (200mg+ more than standard
dose), the intense psychological effects may cause vomiting and induce strong anxiety.
Overall, PEA is not addictive or dependence forming, even when tolerance leads to doses of 2-2.5g, there is no withdrawal or cravings when
discontinuing usage. Dose decreases back down to baseline within two weeks. I like to use it when gaming because it increases focus and I seem to play
a LOT better than without it, but outside of that and for maybe studying, it’s pretty useless. No euphoria is experienced so it has little value as
a recreational substance, and the short duration and high dose means that it isn’t great medicinally. As a pure TAAR1/TAAR2 agonist, PEA obviously
has no psychedelic effects, only stimulant like its methylated cousins.
[Edited on 26-4-2018 by LearnedAmateur] |