Went wlth doing the alkylation first. Will report on the results once the acylation is complete.
That, on the other hand, I am looking forward to much less, considering its butyric anhydride. Never handled the acid, but have heard nothing pleasant
about the odour.
Just awaiting the fixing of my stirplate, which couldn't have picked a more annoying time to stop working. Should be done today though.
Ended up refluxing the alkyl halide with a very little light naphtha, using of all things, a hairdrier on maximum output, since a friend of mine
kindly donated one that can, at least if pointed at human flesh, only be described as vicious. If all, despite the setback, went well, and the product
was alkylated as desired, I think I'll try acylation of just 1/4 of the product (done on a 4g scale, since the piperazine mono-phosphate came
conveniently in 4g packages as de-worming medicine. Even that should be sufficient to verify activity.
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