Sciencemadness Discussion Board

Hydrolysis of 6-MAC

institution - 16-10-2016 at 18:11

Does anybody have an idea how one would go about this? 6-Monoacetylcodeine is an acetate ester of codeine, and it seems like it would be facile to deacetylate it into codeine freebase through hydrolysis. Any ideas?

[Edited on 17-10-2016 by institution]

Metacelsus - 16-10-2016 at 19:53

Why do you want to do this? (I don't want to give advice to criminals.)

Anyway, the conditions for acetate ester hydrolysis are common knowledge. Look them up yourself.

Fidelmios - 16-10-2016 at 21:45

Quote: Originally posted by Metacelsus  
Why do you want to do this? (I don't want to give advice to criminals.)

Anyway, the conditions for acetate ester hydrolysis are common knowledge. Look them up yourself.




Seems sketchy. first post, and asking about precursor syntheses to Oxycodone..

Bert - 2-12-2016 at 12:31

Just a thrifty chemist, trying to make some profitable use of the acetyl codeine he very public spiritedly separated out of quickly labbed, dirty, semi processed batches of heroin before selling it on. Injecting codeine is bad, m'kay? Tends to erode your customer base even quicker than usual to pass that stuff along in the goods.
Quote:
While the acute toxicity of 6-monoacetylcodeine have not been studied in man, animal studies have shown that in animal models it's convulsant effects have been proved and when mixed with mono- or di- acetyl morphine, lowers the convulsant threshold of the mixture still further.[


Yep. Public spirited, thrifty, and trying to get educated. Benjamin Franklin would be proud.



;)


[Edited on 3-12-2016 by Bert]