Sciencemadness Discussion Board - Modafinil (smart drug) synthesis

Modafinil (smart drug) synthesis

Solomon - 25-6-2013 at 19:08

Modafinil is a "smart drug". Modafinil can keep you awake for over 20 hours and increase brain power (although it has been reported to be less effective in people with higher IQs). Modafinil is only available by prescription but I have learned a method by which it can be synthesized. For modafinil synthesis instructions visit: http://www.drugfuture.com/synth/syndata.aspx?ID=129674

Variscite - 25-6-2013 at 19:32

Detritus? Seems like a k3wl/cook.

Solomon - 25-6-2013 at 22:19

I am not saying to synthesize and use it like a conventional drug! It can be used in an emergency for a boost in overall performance (ex: if you are driving in the night and need to stay wake). I would wish any drug lord failure for abusing this substance!!!!!!!!!!!!!! :mad:

Solomon - 25-6-2013 at 22:29

If you are interested in the "super power" like qualities of modafinil then see this video (for the part about modafinil skip to 2:20): http://www.youtube.com/watch?v=X_oBXhtUsTM

gravityzero - 26-6-2013 at 05:42

That appears to be an interesting and refreshing compound. Wikipedia says that it is anything but a classic stimulant and works on the brain chemistry from a totally different perspective to acheive the results.

Comes from a family known as Eugeroics:
Adrafinil
Armodafinil
Modafinil

Thanks for sharing.

Bot0nist - 26-6-2013 at 09:48

I am perscibed armodafinil . I only notice a slight stimulant effect for 6hrs, nervous jitters, and some insomnia that night. No super boosted cognitive abilities though. As far as stimulants go, I find it to be so so. A coworker of mine is perscribed adderal, .and he prefers it over nuvigal, of course, for both stimulation and "hightened brain power."

[Edited on 26-6-2013 by Bot0nist]

Solomon - 26-6-2013 at 10:08

I will learn more about those others gravityzero mentioned. By the way, if anyone is interested in the syntheses of medical supplies, you should download the encyclopedia of pharmaceutical substances. I uploaded the file to a file sharing website located here: http://www.fileswap.com/dl/i4cebSb7S9/ . Make sure you click slow download. The encyclopedia of pharmaceutical substances is 2388 pages of fun, teaching how to synthesise over 3,000 different drugs (Allantoin is a good one located on page 63

). I would say that this book is better than the golden book of chemistry experiments. If you could try modafinil, I think it would be an interesting experiment to take some and then take an IQ test, then wait for it to wear off and then take another IQ test and compare the results to see if modafinil really does significantly increase brain power.

Random - 26-6-2013 at 11:32

Quote: Originally posted by Solomon

If you could try modafinil, I think it would be an interesting experiment to take some and then take an IQ test, then wait for it to wear off and then take another IQ test and compare the results to see if modafinil really does significantly increase brain power.

Maybe only alertness or speed of learning/decisions.

Solomon - 26-6-2013 at 11:40

A test was conducted and the abstract of the results are available here: http://www.ncbi.nlm.nih.gov/pubmed/16140369

chemrox - 26-6-2013 at 21:36

At least now I know why it never worked for me LOL

Solomon - 26-6-2013 at 22:52

Oh I think I get it... you mean you have a high IQ

? Not insulting you... just thinking about what you mean

Solomon - 26-6-2013 at 23:04

I got an IQ score (on WISC for age 15) of:
Verbal reasoning: 128
Perceptual reasoning: 121
Memory: 116
Processing speed: 85
By the way if anyone else has taken an IQ test could you please post your results. I believe that it is statistically unusual in an average population to find people with a high score in both verbal and perceptual reasoning. I hypothesize however that people on the sciencemadness are among the very few who do have a high score in bot verbal and perceptual reasoning categories. I was concerned over posting this as IQ has always been a... sensitive topic. I hope others would post their IQ result categoies on here (if you have taken an IQ test). I took one because the cops found chemicals at my house and nosy freedom destroying robotic people that they are did their governments bidding. They just had me mentally tested. Dirt bags took all my chemicals away :mad:

. Anyway although we are getting off the subject, just post your IQ results and I will make a data chart and post the results on here if I get enough scores

.

[Edited on 27-6-2013 by Solomon]

[Edited on 27-6-2013 by Solomon]

Mildronate - 27-6-2013 at 03:30

This smart drugs is easier to buy.

Number 9 - 27-6-2013 at 04:22

I made trace amounts of modafinil. It don't work the same as amphetamine or methylphenidate. It's a pharmaceutical compound that is used to treat narcolepsy. You simply don't feel tired anymore but it isn't suited as recreational drug. Also the dose is high and nasty side effects might be possible, like the Stevens-Johnson syndrome.

During the synthesis it is pretty hard to deal with that sulfur atom, you can't do it unless you get rid off a vacuumdestillation. Not recommended to make it, to be honest.

Intergalactic_Captain - 27-6-2013 at 05:35

Mean of 115? If this study is true, I'm not sure how interested I am in modafinil - Would be interesting just to see if it would do anything for me...

Never had a standard IQ test, so as such when I was 15 or 16 I took the MENSA test - And was accepted, or passed, or however that all works - You don't get a score, it's based on whether or not you are at or above the 98th percentile average at the time the test is administered - So going by that, ten years or so ago I was at or at least 135...

...Long story short, I never joined - They want something like $65 a year, all I want is the genius card - Pretty sure my intelligence is proven by the fact that I still refuse to pay for it

. . .

Number 9 - 27-6-2013 at 08:13

API's that make you smarter don't exist. There is medication for Alzheimer disease to slow down the breakdown of certain proteins in your brain. But like It's already discussed, it's just a commercial joke to use it as a healthy person.

Modafinil don't make you smarter. Unless you can prove it with a serious, independent peer-reviewed article. Don't believe that YouTube video's, it's mostly faked.

Solomon - 27-6-2013 at 11:16

Number 9 how much modafinil did you synthesize? And to anyone viewing this thread... you should really download the Encyclopedia of pharmaceutical substances. http://www.fileswap.com/dl/i4cebSb7S9/

.

[Edited on 27-6-2013 by Solomon]

blogfast25 - 27-6-2013 at 13:17

Quote: Originally posted by Solomon

I was concerned over posting this as IQ has always been a... sensitive topic.[Edited on 27-6-2013 by Solomon]

[Edited on 27-6-2013 by Solomon]

You mean it's a culturally biased test, used mainly to clobber the 'less intelligent' over the head with?

We can't even define it [intelligence], let alone measure it. Like most old myths it doesn't just want to die quietly though... I suppose it gives a certain type of lab coat donned pseudoscientists something to do, errm... like almost look 'intelligent'.

Manifest - 27-6-2013 at 15:02

Can you guys understand that formula?

How could I go about understanding it?

Solomon - 27-6-2013 at 17:42

sonogashira do you mean that you were 33 points above the average IQ?

DeadHead - 28-6-2013 at 06:59

In a psych class I took, we were administered 3 different shortened IQ tests. These tests were taken from different regions and times. They vary so wildly, it was proof of the point that IQ mean almost nothing, because there is no true way to standardize knowledge. Living in the north, the only person who have a non-embarassing score for the "Southern Region" test was our out of state student from Mississippi. I didn't even understand half of the questions because it incorporated some local slang definitions and such. On the other hand, that student bombed the "Nothern region" test, while the rest of us did fairly well.

Solomon - 28-6-2013 at 08:07

Allantoin is another drug that can be synthesized using the encyclopedia of pharmaceutical substances. Allantoin causes faster cell division, and it may be able to induce division in cells that do not naturally divide. Page 64 states that urea and glyoxylic acid react with hydrochloric acid to form allantoin.

sargent1015 - 28-6-2013 at 08:23

Quote: Originally posted by Solomon

Allantoin causes faster cell division, and it may be able to induce division in cells that do not naturally divide.

Sounds carcinogenic, I'm gonna pass on this one

Solomon - 28-6-2013 at 08:34

A little bit carcinogenic towards your kidney but maybe not if it's handled correctly. Let's say you needed to regrow a tooth cavity. You could surround the tooth with a small "cup" of some safe clay-like material and add allantoin into it. You could then vacuum it out after the tooth cells absorbed a small quantity. After that, you could remove the "cup" around the tooth and blend egg shells with a smoothie to provide an ultra calcium and mineral containing diet necessary to regrow tooth cells. Any courageous attempts at this would be applauded.

AndersHoveland - 29-6-2013 at 00:19

Quote: Originally posted by Solomon

For modafinil synthesis instructions visit: http://www.drugfuture.com/synth/syndata.aspx?ID=129674

Interesting pathway.

What if one were to attach the acetyl group by using acetic acid in acetic anhydride? Under such conditions, acetic acid can be oxidized on the 2- position.

probably here is why the acetic acid can be oxidized under these conditions

CH2=C(OH)-OC(O)CH3

[Edited on 29-6-2013 by AndersHoveland]

Steve_hi - 29-6-2013 at 04:10

Thanks for the link solomon

blogfast25 - 29-6-2013 at 08:39

I'm not sure why this nonsense hasn't been moved to detritus or whimsy yet.

To 'improve your "IQ"', try a placebo:

1. BELIEVE
2. take a sugar pill
3. Presto!

Alternatively, use what you've got but HARDER!

Fantasma4500 - 29-6-2013 at 12:05

Quote: Originally posted by Solomon

I got an IQ score (on WISC for age 15) of:
Verbal reasoning: 128
Perceptual reasoning: 121
Memory: 116
Processing speed: 85
By the way if anyone else has taken an IQ test could you please post your results. I believe that it is statistically unusual in an average population to find people with a high score in both verbal and perceptual reasoning. I hypothesize however that people on the sciencemadness are among the very few who do have a high score in bot verbal and perceptual reasoning categories. I was concerned over posting this as IQ has always been a... sensitive topic. I hope others would post their IQ result categoies on here (if you have taken an IQ test). I took one because the cops found chemicals at my house and nosy freedom destroying robotic people that they are did their governments bidding. They just had me mentally tested. Dirt bags took all my chemicals away :mad:

. Anyway although we are getting off the subject, just post your IQ results and I will make a data chart and post the results on here if I get enough scores

.

[Edited on 27-6-2013 by Solomon]

[Edited on 27-6-2013 by Solomon]

hah.. i thought i was pretty well the only person that was put through that thing.. luckily i got out and could start pointing fingers at the person who was still keeping me improsoned for approx. 1 year from when i was told i had no mental dysfunctions
good times
because they were all a stereotype of sick men.

iQ was measured to be 135, and as soon as something i cant find sense in learning, such as general small talk like.. talking about dogs and such other nonsense doing no good as low as iQ 85

i dont read anything else but an iQ test that cannot lie.. just like ADHD medicine will make you really really energetic if you dont have ADHD, and the opposite if you DO

i read this should be moved to detritus, and i dont see the reason for that, i was very denying about the whole ''drug'' thing, however this is a commercially available ''drug'' and if you compare this to HE, i dont see much problematics with it, others than if this would be mass produced and made profit and cause problems in the society
already im signing out of attempting to make this as its an organic, lol.
but would be cool to have it on your shelf and being able to say you made it..

Solomon - 29-6-2013 at 13:16

antiswat, I am assuming that they arrested you for what I was questioned for. How long ago was this? If it was not too long ago, then you may be able to see the details of your IQ test by requesting a print out of the results from the person who conducted the test. Have you made any impressive explosives (ex: C4, Semtex, RDX, HNIW, Astrolyte, etc...). I feel the same way you do about small talk... useless. Did you join this forum in response to the hydrazine synthesis video like I did? Great post on that pyro handbook... possibly the greatest DIY explosives book that I have ever read. By the way, you can learn how to synthesize truth serum (Thiopental) from the encyclopedia of pharmaceutical substances (p. 2021).

[Edited on 6-29-2013 by Solomon]

Nicodem - 30-6-2013 at 12:44

Unless this thread returns to a chemistry related topic in the next three posts, I'm moving it to the Whimsy section where it apparently belongs.

Mildronate - 1-7-2013 at 00:34

Here is my gift for you

[Edited on 1-7-2013 by Mildronate]

Attachment: modafinil.pdf (447kB)
This file has been downloaded 2164 times

aliced25 - 1-7-2013 at 02:20

If you can get the thioacetamide, then it can be oxidized with peracetic acid

Attachment: Aktoudianakis.Lin.Dicks.Keeping.Your.Students.Awake.Facile.Microscale.Synthesis.of.Modafinil.a.Modern.Anti.Narcoleptic.D (122kB)
This file has been downloaded 1060 times

Solomon - 1-7-2013 at 09:28

Good file Mildronate.

Solomon - 1-7-2013 at 12:33

Processing speed is only useful in sports. It is debatable whether that should even be considered as a category on the IQ test. One person figured my average at 112 which would be right unless processing speed didn't account for very much. As they pay little attention to processing speed when calculating the cumulative IQ, thus the reason why my cumulative score was 119. On the first IQ test I took, the cumulative score was 125 because they didn't include processing speed. This discussion is getting exceedingly unproductive and becoming a waste of time! Let's get back to chemistry! No more IQ comments unless it is a detailed report of an IQ score with a pdf of your results! Someone think of another chemistry topic and we can start discussing, preferably something regarding synthesis.

[Edited on 7-1-2013 by Solomon]

[Edited on 7-2-2013 by Solomon]

[Edited on 7-2-2013 by Solomon]

Attachment: IQ results.pdf (154kB)
This file has been downloaded 717 times

[Edited on 7-2-2013 by Solomon]

Vargouille - 2-7-2013 at 05:05

It's confidential for a reason, mate. I would black out your name and high school at the very least.

sonogashira - 2-7-2013 at 05:07

I'm sure he'll get around to it. His substandard "processing speed" might be to blame?

sargent1015 - 2-7-2013 at 05:10

This thread has been derailed hard, detritus?
Or just lop off the bad parts

Vargouille - 2-7-2013 at 16:58

That's fixed some of it, but the way you blocked out your high school means that it's relatively simple to find out the name of whose computer you used to do it. I'm guessing your father. I would do it in MS Paint and repost as a .jpeg or something like that. Also, I wouldn't want to have my full name visible, either. It probably seems a bit much, all of this, but there are some scary people out there.

ChemistryGhost - 5-8-2017 at 19:51

Modafinil really is a smart drug. It's safer than coffee. It's also good for enhancing wakefulness, and making the brain work more efficiently. Also, it's especially useful for ADHD.
I have ADHD, and Modafinil has been pretty good. My brother has ADHD too. My cousin from Canada he has ADHD. My other cousin, she has ADD. There are a lot of geniuses in my family with ADHD. The modafinil feels kinda relaxing to me, but also boost focus and memory and you can more productively use your pre-existing intelligence. Modafinil has been one of the best things ever and prevents me from being volatile and forgetful.
https://www.livescience.com/51919-modafil-improves-attention...
https://www.ncbi.nlm.nih.gov/pubmed/16623645
Flodafinil is a good alternative to modafinil.
I think benzhydrol could be a starting point to modafinil synthesis.
For improving IQ, the most effective way is neurogenesis that can create robust improvements permanently. NSI-189, 9-Me-BC, and Selank are some examples of neurogenesis. Phenylpiracetam is also useful.
Stacking cognitive enhancers with memantine would be better than taking cognitive enhancers alone, to protect against potential neurotoxicity by preventing excess glutamate. Taking turmeric and piperine at the end of the cognitive enhancer dose can help prevent negative epigenetic changes by creb inhibition and preventing dynorphins from being released.
.
Future research will allow for the hypothetical ceiling of happiness to be raised to superhappiness and beyond. Laser neurosurgery will reduce physical and emotional pain and suffering and also substantially reduce pain from rejection. Laser neurosurgery will cure OCD and NPD and BPD. Deep brain stimulation can improve the brain. Future chemistry can allow for superhappiness, superintelligence, superhealth, superstrength, and superlongevity. Titanium foam bones build wolverine bones. A future with virtually no tolerance. A future where most of the fear and suffering is neurosurgically and technologically and chemically removed from the brain and could be replaced with brain chip functional analogues.
.
There's also PF-4455242.
Epigenetics suggests that what we do and other factors can affect the modification of gene expression. It's preferable in most cases to modify the gene expression rather than altering the gene itself. There are good epigenetic changes and bad epigenetic changes. The aim is to reduce the negative epigenetics and increase the positive epigenetics.
.
Future compounds will revolve around epigenetics and be much more accessible, stable, and affordable than genetic engineering. Hence, 9-Me-BC and lion's mane and semax and more will be much more stable than gene editing.
.
There is also the possibility that robots will lead to a universal basic income.
.
Better living through chemistry. Transhumanism. Utopian neurosurgery. Science. And more.
.
It's difficult to make it without proper help despite a very high intelligence if there's ADD/ADHD. Hence, professional help may be needed.
http://www.addvance.com/help/parents/gifted_child.html
.
Benzhydrol could be a starting point to modafinil synthesis.

Texium - 5-8-2017 at 21:22

Looks like 4 years later I finally get to do the right thing and move this thread to Detritus where it belongs. Thanks for bumping it, ChemistryGhost.

Bert - 16-11-2017 at 07:47

This really is not a cooking chemistry ban worthy topic. I STARTED to move a collection of merely drug related but not beyond the pale/obviously detritus worthy stuff back to original (or at least appropriate?) forums. Then stopped, because, second guessing another moderator. Not a good thing.

I would welcome some discussion on where we stand in this matter.

I personally have i$$ue$ with some a$pect$ of "drug culture", and so am not unbiassed- but still quite interrested in the nuts and bolts of both synthesis and biological/perceptual effects of substances- No matter what politicians think they should do to get re elected.

[Edited on 16-11-2017 by Bert]

Texium - 16-11-2017 at 10:25

It didn't seem too controversial to me. There were multiple calls to send it to Detritus years ago, it got bumped this year with a sort of odd stream-of-consciousness block of text about the wonders of "smart-drugs," and thus I sent it to Detritus, thinking that it must have just been missed by the mods in 2013.

clearly_not_atara - 16-11-2017 at 11:23

I hate to be the bearer of bad news, but modafinil is a Schedule IV drug in the United States. It's not recreational, but then again lots of things are scheduled for stupid reasons. Whether it's allowed is mod's discretion of course but I thought people should be aware.

With that said, ammonium thioglycolate is a key component of many hair removers. Perhaps this can be pyrolyzed to thioglycolamide? That would only require a reaction with benzhydryl bromide and oxidation of the product to arrive at modafinil.

zed - 22-11-2017 at 15:59

Well, small amounts of amphetamines and whatnot, will over time, probably make you smarter.

Though there is such a thing, as being too smart.

Nice to have a super fast car with a really powerful engine. While keeping in mind, that such a car, will need really, really, really...good brakes.

If you can't slow yer noggin down; then to a bad place...... you will be a-going.

https://www.poetryfoundation.org/poems/49303/howl

[Edited on 22-11-2017 by zed]

[Edited on 23-11-2017 by zed]

aga - 22-11-2017 at 16:02

Drugs are bad m'kay ?

zed - 22-11-2017 at 16:26

Not bad exactly. Kinda like snakes. Useful on occasion, but you gotta remember that the snake has a toothsome end on it. Try not to tempt fate.

https://www.youtube.com/watch?v=eRGeIrAfq-k&list=PLA643C...

Bert - 22-11-2017 at 17:33

The knife that cuts the mistresse's throat is the same that the wife peels potatoes for the children's dinner with?

[Edited on 23-11-2017 by Bert]

LearnedAmateur - 23-11-2017 at 07:15

I know I'm not really in a position to call any shots, but I think it should be scrutinised if questions about personal usage are asked, I mean this isn't Bluelight, and it's never recommended to ingest anything you make yourself unless you have access to the equipment to ensure absolute purity. However, I don't see anything wrong with discussing the syntheses of any compound, no matter how controversial, dangerous, and/or illegal by users who obviously know what they're talking about - especially considering that explosives are a hot topic on SM and in a way are far more dangerous than many drugs and toxins/poisons. That's when it's obvious that there is a distinction between those who have a genuine interest in the chermistry behind these substances, I know I do, and those who just want to know what powders and liquids to throw into a jar overnight. Flexibility in the rules leads to freedom by those who deserve it, but it can still be tightly controlled based on context and background; what one user may consider completely illegal and taboo, another could view as tolerable and utterly benign simply due to their location, level of knowledge, and other varied circumstances. Just my thoughts on the issue, since at the end of the day we all sit under the same umbrella and are more alike than one may care to admit.

S.C. Wack - 23-11-2017 at 09:27

There are sadly lame threads started here all the time and I think that's the actual issue here. Nothing exceptional about this one though, and the patent could be an interesting jag of madness if one at least had benzoic acid and thiourea.

zed - 25-11-2017 at 17:53

I don't want to be an advocate; a Judas Goat, leading my companions to slaughter.

On the other hand, I don't want to be reactionary.

I think it is important to temper the public's enthusiasm for "Happy" chemicals, with a little punch-in-the-face reality...... You are on the edge, watch your step. You too can ruin your life, and/or die young.

I live in one of America's hippist cities. I input.

When Nancy Reagan says "Just say No!" It falls on deaf ears.
When William S. Burroughs tells you "It's time to clean-up, kid!" "You are about done for!" It should provoke self evaluation.

[Edited on 27-11-2017 by zed]

Metacelsus - 26-11-2017 at 06:58

For modafinil in particular:

Taking it doesn't actually make one smarter, despite the popular belief that it does. Modafinil helps with two things. First, it improves mental stamina, allowing one to focus on mentally demanding work for longer periods of time. Second, it promotes wakefulness.

I almost forgot -- modafinil does a third thing as well. It makes one's urine have a unique, but thankfully not too unpleasant, odor.

Texium - 26-11-2017 at 07:24

Quote: Originally posted by S.C. Wack

There are sadly lame threads started here all the time and I think that's the actual issue here. Nothing exceptional about this one though, and the patent could be an interesting jag of madness if one at least had benzoic acid and thiourea.

That's why I sent it to Detritus in the first place... it's a lame thread. A complete mess, too. Here is a perfectly good thread about modafinil that I have no objection to: https://www.sciencemadness.org/whisper/viewthread.php?tid=61...

See the difference?

[Edited on 11-26-2017 by zts16]

zed - 26-11-2017 at 16:34

Ummm. Sometimes serendipity spins straw into golden thread.

True, this thread lacks scientific merit. But, we might not want to corrupt a really nifty thread with social commentary, or degenerate music.

Manufacture better people, not better drugs.

http://babylonfalling.tumblr.com/post/426418482/street-corne...

Sorry guys. The Devil made me do it.
[Edited on 27-11-2017 by zed]

[Edited on 27-11-2017 by zed]

[Edited on 27-11-2017 by zed]

[Edited on 27-11-2017 by zed]

[Edited on 27-11-2017 by zed]