thorazine - 22-3-2012 at 12:29
Hi,
at the university my friend is trying to prepare little quantities of cathinones to standards.
The first is MDPV, he boiled piperonylonitrile with n-BuMgCl in toluene for a couple of hours and then put the product into ice (to stop the
Grignard's) and add H2SO4 conc. to hydrolyze. By TLC he saw that piperonylonitrile isn't there anymore, but it isn't
1-(3,4-Methylenedioxyphenyl)-4-methyl-1-pentanone [that is what he needs to produce MDPV]. He didn't find much information on web and in papers so he
asked me to ask here. Anyone knows some paper with this kind of reaction?
thanks!
GreenD - 22-3-2012 at 12:42
... How do you know its not? What did TLC show, no product?
I'm assuming you took the necessary grignard precautions and set up?