mrzwing - 28-3-2025 at 22:19
I'm looking into the decarboxylation reaction and just wonder if i am on the right track with something that come to mind.
I see some reactions where they create a more acidic environment before heating, is it that the acidic environment gives an access of H+ ions to aid
the substitution.
sorry if i use the incorrect terms.
Osmiridium - 29-3-2025 at 04:09
Which compound do you want to decarboxylate?
The conditions may vary since some carboxylic acids decarboxylate easily while others do not. But usually heat and dry distillation is involved.
mrzwing - 31-3-2025 at 04:53
i'm looking in to ibotenic acid decarboxylation, read a study where the efficiency and amount och decarboxylation of ibotenic acid to muscarine was
much higher if the mixture was at a ph lower than 3 if i remember correctly during heating.
and made me think if it was the excess of h+ ions that would help the process.
Lionel Spanner - 2-4-2025 at 15:16
Since it's an alpha-amino acid, it could in theory be decarboxylated in a solvent with a boiling point of at least 150 °C, with an α,β-unsaturated
ketone as a catalyst. Without the catalyst, this reaction doesn't take place until well over 200 °C.
From experience I have found yields and reaction times for a given solvent are wildly variable, depending on the nature of the acid.