Sciencemadness Discussion Board

Epimerization of 10-hydroxycodeine

MKChemist - 19-11-2024 at 02:49


Is the mechanism of Epimerisation of the -OH at C10 of 10-hydroxycodeine known. Can someone elaborate. With different preparation of standard of Codeine Impurity E (the manufacturer doesn't state if it is in alpha or beta form), different ratio of the alpha and beta form are detected on HPLC.

epimerization-of-10-hydroxycodeine.png - 103kB