slyder - 5-9-2021 at 06:19
Hello,
Can someone confirm would this synthesis work in order to obtain enatioselective ( ee 99% ) R-PAC from R-mandelic acid --> Weinerb amide -->
methyl grignard ---> R-PAC ?
Thanks !
Cheers ! 
Texium - 5-9-2021 at 07:22
It should work if you protect the alcohol first.
slyder - 5-9-2021 at 07:49
Texium thanks for reply.
Protection with sillyl group eg. tert-Butyldimethylsilyl chloride ( TBDMSCl ) or tetrahydropyranyl ether will be OK in my opionion because is the
most easiest to remove ?