Sciencemadness Discussion Board

Is it possible to synthesize trimethyl phosphate via transesterification

CRN114-Discriminator - 4-1-2021 at 16:54

The title pretty much says it all. I was thinking of a way to synthesize this sans POCL3 and transesterification crossed my mind. Professor Google was not able to answer my question. So here I am. Thank you in advance.

Pumukli - 4-1-2021 at 22:21

Interesting idea, maybe worth entertaining a bit further.

Question is if a route exists to say tributyl phosphate via azeotropic esterification (to circumvent POCl3) AND another to trimethyl phosphate through say a base-catalised transesterification step...


CRN114-Discriminator - 5-1-2021 at 15:17

Thanks for the idea. I spent a bit of time before bed looking into it.

I was also thinking about whether or not in situ generated dimethyl sulfate would react with trisodium phosphate to generate it. Any thoughts?

Corrosive Joeseph - 6-1-2021 at 07:33

You might like this.... - https://www.sciencemadness.org/whisper/viewthread.php?tid=15...



/CJ