crazedguy - 9-2-2011 at 18:58
http://en.wikipedia.org/wiki/Myostatin
There have been test on animals that show Myostatin blockers used twice cause a 50 % growth in animals.
Does anyone know viable myostatin blockers, or something that would have it in them.
Regolith - 28-2-2011 at 23:09
My apologies I've been busy in another thread where I had forgotten the reason I'm here.
I've been doing Myostatin research since 2002. I have significant data as well as a nearly completed paper on the expression of the
myostatin containing allele in Gerbil. Including animals that have been bred and/or modified to show the expression in several forms.
In gerbil and human the expression is similar it does more than a 50% growth over the whole body, heart muscle tissue (interestingly) seems to not be
fully affected. The effect causes more of a muscle doubling, for an example the silverback gorilla has a very lowered myostatin
expression and/or the myostatin created is faulty and non functional.
Your not going to find the blocking drug form. It was tested for awhile some time ago and not put into common production by the drug
company Wyeth. Stupid considering those with advanced wasting diseases would likely gladly take the risks, instead of certain death. The best you can
get is to either create and multiply the myostatin antibody or use a soluble molecule that binds myostatin. The danger of both and perhaps why the
drug Co. didn't start mass production is it extremely aggravates (not all forms, but some) existing benign tumours (in a few forms of cancer it's
found they do there own suppression of myostatin locally to expand faster).
A german child was born to parents both having half of the blocking gene themselves, the father was so strong as to unload
curb stones by hand and his mother was a gymnast. Their child by now would be several years old, pictures of his
legs and arms are available showing his toddler body of impressive muscle size. They sheltered him from publicity after the discovery (wisely).
In nature a form of the blocking protein (follistatin) grows in a common soil fungus when allowed to grow in an anaerobic
environment. In the wild said fungus dies upon exposure to UV and must be produced in growing media and total darkness. If you would like I can post
some of the research as well as pictures of the animals. I'm not sure this is what your after.
drmisc - 10-12-2011 at 05:15
hey Regolith, I am extremely interested in your research, could you please post some of the research as well as the pictures of the animals? thanks.
Chemstudent - 5-3-2012 at 13:19
This is an area I've always looked at with GREAT interest. I've seen underground peptide manufacturers in US and abroad make synthesize Follistatin in
1-5mg portions, as well as GDF-8 Binding Protein, and Stamulumab (prototype drug) sold to bodybuilders and whomever interested in being a guinea pig.
Interesting logs of such use can be found on www.professionalmuscle.com
However the consensus seems to be that to get a truly effective "inhibitor" of myostatin, one would need to get an Adeno associated virus to replicate
a GDF-8 binding protein. There is where much success has been seen in rat studies, unfortunately no human studies yet but I'd gladly volunteer in a
heartbeat! Double muscle??? I'm in! 