Johnny Windchimes - 28-5-2019 at 03:16
Good day all,
I would like to substitute HCl acid in for H2SO4 acid for the hydrolysis portion of the referenced synthesis of 1-Phenyl-1,2-Propanedione from
Isonitrosopropiophenone.
If memory serves this should not be an issue mole for mole if the amount is doubled owing to H2SO4 acid having an extra proton vs. HCl acid, yes?
Reference: Organic Syntheses, Coll. Vol. 3, p.20 (1955); Vol. 23, p.1 (1943). W. W. Hartman and L. J. Roll.
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[Edited on 28-5-2019 by Johnny Windchimes]
Tsjerk - 28-5-2019 at 03:21
This won't work one on one, at least the workup won't. Sulfuric acid doesn't come over in the steam distillation, HCl will.
Johnny Windchimes - 28-5-2019 at 03:23
Very true. Thanks for reminding me of the basics haha