DrGandham - 29-3-2019 at 23:01
Hello there,
I am working on N-Arylation of alpha amino acids and peptide coupling to synthesize a molecule. Could any body suggest me how to minimize the
racemization of amino acid(ester) during N-arylation and peptide coupling. I am trying both traditional (thermal) and Buckwald coupling for
N-arylation.
Metacelsus - 30-3-2019 at 00:23
Racemization involves deprotonation at the alpha carbon. The racemization rate is thus a function of pH (and of course temperature). You should try to
avoid strong bases and high temperatures.