Sciencemadness Discussion Board

acetylsalicylic acid without AA?

libavius - 6-3-2010 at 16:02

For the acetylation of salicylic acid to acetylsalicylic acid is always used acetic anhydride.
Believe that it is somehow possible to use acetic acid instead of AA?

JohnWW - 6-3-2010 at 19:51

You just might be able to get away with using glacial acetic acid, plus a small amount of H2SO4 as a catalyst and to mop up the water of reaction.

Vogelzang - 7-3-2010 at 13:16

See the attached articles.



Attachment: JCE1964-phenol-esterification.pdf (937kB)
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Attachment: JCE1980-phenylacetate.pdf (1.2MB)
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libavius - 7-3-2010 at 15:35

Very informative articles, many thanks!

Vogelzang - 8-3-2010 at 02:57

If you're interested in the Fries rearrangement with hydroquinone derivatives see the attached article.

Attachment: EurPolymerJ-1996-p735-746.pdf (1.2MB)
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