Sciencemadness Discussion Board

aldol condensation with aceton and methanal

jhullaert - 29-8-2009 at 01:58

Is it possible to do this reaction?

Formation of 1,5-dihydroxy-2,2,4,4-tetrakis(hydroxymethyl)pentan-3-one. The tetrakis sounds so weird. :P

not_important - 29-8-2009 at 03:21

yes, as a Web search would show you. A wide range of possible produces exists, depending on catalyst and conditions, your target is only mentioned as a minor product if at all.


Aldol condensation reactions of acetone and formaldehyde over vanadium phosphate catalysts: Comments on the acid–base properties
http://www.rsc.org/publishing/journals/CP/article.asp?doi=b1...


doi:10.1016/S0169-1317(98)00035-0


Aldol condensation of acetone over layered double hydroxides of the meixnerite type
doi:10.1016/S0169-1317(98)00035-0



jhullaert - 29-8-2009 at 04:13

Thanks a lot. Very interesting link.

What other ways are there to produce: 1,5-dihydroxy-2,2,4,4-tetrakis(hydroxymethyl)pentan-3-one ?