LOS ALAMOS SCIENCE, NUMBER 20, 1992
The Human Genome Project
Cover page and front matter
(PDF 539Kb)
The Los Alamos Center for Human Genome Studies
(PDF 217Kb)
Contents
(102Kb)
Understanding Inheritance: An Introduction to Classical and Molecular Genetics
(PDF 3.8MB)
Part 2
(PDF 2.9MB)
Early Ideas About Heredity
(PDF 115Kb)
The Variety of Cells
(PDF 459Kb)
Components of Eukaryotic Cells
(PDF 109Kb)
The Eukaryotic Cell Cycle
(PDF 93Kb)
Chromosomes: The Sites of Hereditary Information
(PDF 181Kb)
Mitosis
(PDF 81Kb)
Meiosis
(PDF 95Kb)
Mendelian Genetics
(PDF 235Kb)
Inheritance of Mendelian Disorders
(PDF 177Kb)
Crossing Over: A Special Type of Recombination
(PDF 78Kb)
Determining a Genetic Distance
(PDF 191Kb)
DNA: Its Structure and Components
(PDF 309Kb)
DNA Replication
(PDF 161Kb)
Protein Synthesis
(PDF 324Kb)
The Genetic Code
(PDF 98Kb)
Restriction Enzymes
(PDF 89Kb)
Gel Electrophoresis
(PDF 224Kb)
Hybridization Techiques
(PDF 164Kb)
The Anatomy of a Eukaryotic Protein Gene
(PDF 106Kb)
Mapping the Genome: The Vision, the Science, the Implementation
(PDF 1.2Mb)
I: What is the Genome Project?
(PDF 3.0MB)
Classical Linkage Mapping
(PDF 568Kb)
Modern Linkage Mapping
(PDF 370Kb)
Informativeness of Polymorphic DNA Markers
(PDF 207Kb)
II: Maps, Markers, and the Five-Year Goals
(PDF 3.7Mb)
Physical Mapping, a One-Dimensional Jigsaw Puzzle
(PDF 771Kb)
The Polymerase Chain Reaction and Sequence-tagged Sites
(PDF 703Kb)
YAC Library Pooling Scheme for PCR-Based Screening
(PDF 166Kb)
cDNAS and Expressed Genes
(PDF 86Kb)
III. Technological Challenges in the Genome Project
(PDF 2.4Mb)
DNA Sequencing
(PDF 771Kb)
IV. Implications for Biology and Society
(PDF 2.4Mb)
Unraveling the Chromosome
(PDF 1.3Mb)
The Mapping of Chromosome 16
(PDF 2.8MB)
Part 2
(PDF 2.2Mb)
Various Classes of Human Repetitive DNA Sequences
(PDF 180Kb)
Collaborations on the Isolation of Disease Genes on Chromosome 16
(PDF 190Kb)
What's Different About Chromosome 16?
(PDF 449Kb)
Mapping Chromosome 5
(PDF 275Kb)
DNA Libraries: Recombinant Clones for Mapping and Sequencing
(PDF 3.2Mb)
Libraries from Flow-sorted Chromosomes
(PDF 776Kb)
Computation and the Genome Project
(PDF 3.4Mb)
Part 2
(PDF 1.7Mb)
Decades of Nonlinearity: The Growth of DNA Sequence Data
(PDF 177Kb)
SCORE: A Program for Computer-Assisted Scoring of Southern Blots
(PDF 1.9Mb)
SIGMA: System for Integrated Genome Map Assembly
(PDF 365Kb)
Electronic Data Publishing in GenBank
(PDF 237Kb)
Rapid DNA Sequencing Based on Single-Molecule Detection
(PDF 2.6Mb)
Single-Molecule Spectroscopy in Solution
(PDF 1.3Mb)
Members of the Human Genome Center at Los Alamos National Laboratory
(PDF 1.1 Mb)
ELSI: Ethical, Legal, and Social Implications
(PDF 3.4Mb)
An Invitation to Genetics in the 21st Century
(PDF 3.0Mb)
Glossary
(PDF 1.1 Mb)
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